6-Methoxyquinoline

6-Methoxyquinoline Basic information

Product Name:	6-Methoxyquinoline
Synonyms:	6-METHOXYQUINOLINE;Methoxyquinoline,95%;6-Methoxyquinoline, 98+%;6-quinanisole;6-Methoxyquinoline, 98% 25GR;NSC 1954;6-Methoxyquinoline6-;6-Methoxy-1-azanaphthalene
CAS:	5263-87-6
MF:	C10H9NO
MW:	159.18
EINECS:	226-077-2
Product Categories:	Chemical Amines;Alkoxyquinolines;Quinolines;Amines;Aromatics;Building Blocks;Quinoline&Isoquinoline;Heterocyclic Building Blocks;5263-87-6
Mol File:	5263-87-6.mol

6-Methoxyquinoline Chemical Properties

Melting point	18-20 °C (lit.)
Boiling point	140-146 °C/15 mmHg (lit.)
density	1.15 g/mL at 20 °C (lit.)
refractive index	n20/D 1.625(lit.)
FEMA	4640 \| 6-METHOXYQUINOLINE
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	soluble in Alcohol
pka	5.03(at 20℃)
form	Granular Powder
color	White to cream
Odor	heavy sweet
Water Solubility	insoluble
Sensitive	Light Sensitive
JECFA Number	2157
BRN	115244
LogP	2.17
CAS DataBase Reference	5263-87-6(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 6-methoxy-(5263-87-6)
EPA Substance Registry System	Quinoline, 6-methoxy- (5263-87-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	23-24/25-36-26
WGK Germany	3
F	8
TSCA	Yes
HS Code	29334990

MSDS Information

Provider	Language
6-Methoxyquinoline	English
ACROS	English
SigmaAldrich	English
ALFA	English

6-Methoxyquinoline Usage And Synthesis

Chemical Properties	colorless to light yellow liquid
Uses	6-Methoxyquinoline is a useful sythetic intermediate
Uses	6-Methoxyquinoline is used as a precursor in the synthesis of: Fluorescent zinc and chlorine sensors. 5-Amino-2-aroylquinolines as potent tubulin polymerization inhibitors. 3-Fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase. Cobalt-based ternary metal-organic complex as single?ion magnets.
Definition	ChEBI: An aromatic ether that is quinoline substituted at position 6 by a methoxy group.
Synthesis Reference(s)	Journal of the American Chemical Society, 68, p. 1584, 1946 DOI: 10.1021/ja01212a062

6-Methoxyquinoline Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Sulfuric acid-->Toluene-->Sodium nitrite-->Acetic anhydride-->Benzene-->FUMING SULFURIC ACID-->Glycerol-->Sodium iodide-->p-Anisidine-->Orthoboric acid-->4-Nitroanisole-->6-METHOXY-1,2,3,4-TETRAHYDROQUINOLINE-->TRIS(3‐HYDROXYPROPYL)AMINE-->Benzenamine, 4-methoxy-N-2-propyn-1-yl-
Preparation Products	6-Hydroxyquinoline-->Benzenamine,4-methoxy-N-2-propen-1-yl-

8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acid 8-(4-AMINO-1-METHYLBUTYLAMINO)-6-METHOXYQUINOLINE DIPHOSPHATE 6,9-Dichloro-2-methoxyacridine 4-HYDROXY-6-METHOXYQUINOLINE 6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE Mepacrine hydrochloride 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID 6-Methoxyquinaldine 4-CHLORO-6-METHOXYQUINOLINE 6-METHOXY-2-QUINOLINECARBONITR 6-METHOXYQUINOLINE N-OXIDE 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n PINACRYPTOL YELLOW 6-CHLORO-9-[3-(2-CHLOROETHYLAMINO)PROPYLAMINO]-2-METHOXYACRIDINE DIHYDROCHLORIDE 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID 6-Methoxyquinoline 4-CHLORO-6-METHOXY-2-PHENYLQUINOLINE 6-METHOXY-8-NITROQUINOLINE

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