ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Aminopyrimidine 4-(3-Pyridinyl)-2-aminopyrimidine

4-(3-Pyridinyl)-2-aminopyrimidine

4-(3-Pyridinyl)-2-aminopyrimidine Basic information
Product Name:4-(3-Pyridinyl)-2-aminopyrimidine
Synonyms:BUTTPARK 41\09-83;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE;4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE;4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;4-(3-Pyridyl)-2-pyrimidinamine;4-(3-Pyridinyl)-2-aminopyrimidine;4-(3-Pyridyl)-2-pyrimidineamine
CAS:66521-66-2
MF:C9H8N4
MW:172.19
EINECS:1312995-182-4
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:66521-66-2.mol
4-(3-Pyridinyl)-2-aminopyrimidine Structure
4-(3-Pyridinyl)-2-aminopyrimidine Chemical Properties
Melting point 189-191 °C
Boiling point 439.9±37.0 °C(Predicted)
density 1.259±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka2.76±0.10(Predicted)
color Off-White to Pale Yellow
InChIInChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
InChIKeyLQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILESC1(N)=NC=CC(C2=CC=CN=C2)=N1
Safety Information
Hazard Codes T
Risk Statements 25-20/21/22
Safety Statements 45-36/37
HS Code 29339900
MSDS Information
4-(3-Pyridinyl)-2-aminopyrimidine Usage And Synthesis
Chemical PropertiesWhite to off-white or brown solid.
Uses4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.
4-(3-Pyridinyl)-2-aminopyrimidine Preparation Products And Raw materials
Preparation Products4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester-->Imatinib
4-(PYRIDIN-3-YL)-5-[3-(TRIFLUOROMETHYL)BENZENESULPHONYL]-2-PYRIMIDINAMINE 5-(QUINOXALIN-2-YL)-4-(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)PYRIMIDINE-2-AMINE N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 5-(PYRIMIDIN-4-YL)-4-(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)PYRIMIDINE-2-AMINE 5-[(4-METHYLPHENYL)SULPHONYL]-4-(PYRIDIN-3-YL)-2-PYRIMIDINAMINE 3-Aminopyridine 5-(QUINOLIN-4-YL)-4-(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)PYRIMIDINE-2-AMINE 2-Aminopyrimidine 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE 5-(PYRIDIN-4-YL)-4-(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)PYRIMIDINE-2-AMINE 4-(5-BROMOPYRIDIN-3-YL)PYRIMIDIN-2-AMINE 2-Aminopyridine 4-(3-Pyridinyl)-2-aminopyrimidine GLEEVEC ANALOGUE Molasses 4,6-BIS-(6-METHOXY-PYRIDIN-3-YL)-PYRIMIDIN-2-YLAMINE 4-Dimethylaminopyridine
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