7-CHLORO-4-HYDRAZINOQUINOLINE

7-CHLORO-4-HYDRAZINOQUINOLINE Basic information

Product Name:	7-CHLORO-4-HYDRAZINOQUINOLINE
Synonyms:	LABOTEST-BB LT00452674;BUTTPARK 45\09-14;1-(7-CHLORO-4-QUINOLYL)HYDRAZINE;7-CHLORO-4-HYDRAZINOQUINOLINE;TIMTEC-BB SBB000320;7-chloro-4-hydrazino-quinolin;7-chloro-4-quinolylhydrazine;(7-chloro-4-quinolinyl)hydrazine
CAS:	23834-14-2
MF:	C9H8ClN3
MW:	193.63
EINECS:
Product Categories:	Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines;QuinolinesHeterocyclic Building Blocks
Mol File:	23834-14-2.mol

7-CHLORO-4-HYDRAZINOQUINOLINE Chemical Properties

Melting point	219-225 °C (dec.) (lit.)
Boiling point	413.5±25.0 °C(Predicted)
density	1.430±0.06 g/cm3(Predicted)
pka	6.70±0.50(Predicted)
CAS DataBase Reference	23834-14-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-37/39
WGK Germany	3
RTECS	VB2900000
HS Code	2928009090

MSDS Information

Provider	Language
SigmaAldrich	English

7-CHLORO-4-HYDRAZINOQUINOLINE Usage And Synthesis

Uses

7-Chloro-4-hydrazinoquinoline was used in the preparation of new Schiff base hydrazone ligand via reaction with o-hydroxybenzaldehyde. It was also used in the preparation of N′-(E)-heteroaromatic-isonicotinohydrazide derivatives and the heteroaromatic 7-chloro-4-quinolinylhydrazone derivatives.

Synthesis

7-chloro-4-hydrazinoquinoline is prepared byhydrazine monohydrate and 4,7-dichloroquinoline in absolute ethanol.Hydrazine monohydrate (2022 mg, 40.0 mmol) and 4,7-dichloroquinoline (800 mg, 4.00 mmol) were dissolved in absolute ethanol (50 ml). The reaction mixture was left under reflux until the reaction has gone to completion and then allowed to cool in the ice bath for crystallization to occur.
(676 mg, 87%): mp: 220 – 225 ℃ (Lit.: 223 – 225 ℃); vmax/cm-1 3320 w (N-H), 3050 w (aro. C-H), 1607 m (C=N), 1448 (m, aro. C=C); δH (300 MHz; DMSO-d6) 11.09 (br. s., NH), 8.56-8.40 (2H, m, C(5)H and C(2)H), 7.97 (1H, d, J 1.9, C(8)H), 7.70 (1H, dd, J 9.0, 1.9, C(6)H), 7.10 (1H, d, J 7.2, C(3)H), 5.31 (br. s., NH); δC (75 MHz; DMSO-d6) 155.7 (Ar-C), 142.4 (C(2)H), 138.7 (Ar-C), 137.6 (Ar-C), 126.4 (C(6)H), 125.3 (C(5)H), 119.1 (C(8)H), 113.6 (Ar-C), 98.1 (C(3)H); m/z (-ES) 194 (100%, [M+H]- with 35Cl), 196 (27%, [M+H]- with 37Cl); found by +ES 194.0475, C9H9ClN3 ([M+H]+ with 35Cl), requires 194.0480, error 2.6 ppm.

7-CHLORO-4-HYDRAZINOQUINOLINE Preparation Products And Raw materials

7-CHLORO-4-HYDRAZINOQUINOLINE

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