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| | 3β-Hydroxyurs-12,19-dien-28-oic acid Basic information |
| Product Name: | 3β-Hydroxyurs-12,19-dien-28-oic acid | | Synonyms: | 3β-Hydroxyurs-12,19-dien-28-oic acid;Sanguisorbigenin;Tomentosolic acid;Ursa-12,19-dien-28-oic acid, 3-hydroxy-, (3β)-;19-Dehydroursolic acid;19-dien-28-oic acid;3β-Hydroxyurs-12;Ursa-12 | | CAS: | 6812-98-2 | | MF: | C30H46O3 | | MW: | 454.7 | | EINECS: | | | Product Categories: | | | Mol File: | 6812-98-2.mol |  |
| | 3β-Hydroxyurs-12,19-dien-28-oic acid Chemical Properties |
| Melting point | 267-268 °C (decomp) | | Boiling point | 563.4±50.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | pka | 4.49±0.70(Predicted) |
| | 3β-Hydroxyurs-12,19-dien-28-oic acid Usage And Synthesis |
| Biological Activity | Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].
The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1]. | | References | [1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244. |
| | 3β-Hydroxyurs-12,19-dien-28-oic acid Preparation Products And Raw materials |
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