ChemicalBook Product Catalog Chemical Reagents Organic reagents Amide N,N-Dimethylformamide dimethyl acetal

N,N-Dimethylformamide dimethyl acetal

N,N-Dimethylformamide dimethyl acetal Basic information
Product Name:N,N-Dimethylformamide dimethyl acetal
Synonyms:Dimethoxy(dimethylamino)methane;N,N-Dimethylfirmanmidedimethylacetal;N,N-Dimethylformamide dimethyl acetal, ca 97%;Methanamine, 1,1-dimethoxy-N,N-dimethyl-;esterate m;n,n-dimethylformamide dimethyl acetal solution;N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL (DMF-DMA);1,1-Dimethoxytrimethylamin
CAS:4637-24-5
MF:C5H13NO2
MW:119.16
EINECS:225-063-3
Product Categories:N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents);(intermediate of zaleplon);Aliphatics;blocks;BuildingBlocks;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Analytical Chemistry;Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents;4637-24-5
Mol File:4637-24-5.mol
N,N-Dimethylformamide dimethyl acetal Structure
N,N-Dimethylformamide dimethyl acetal Chemical Properties
Melting point -85°C
Boiling point 102-103 °C/720 mmHg (lit.)
density 0.897 g/mL at 25 °C (lit.)
vapor pressure 34.5hPa at 20℃
refractive index n20/D 1.396(lit.)
Fp 45 °F
storage temp. Store below +30°C.
solubility Miscible with most organic solvents.
pka5.00±0.50(Predicted)
form Solid
color White to off-white
PH7 (H2O)
explosive limit1.3-17.7%(V)
Water Solubility hydrolysis
Sensitive Moisture Sensitive
BRN 506020
Exposure limitsACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
LogP0.750 (est)
CAS DataBase Reference4637-24-5(CAS DataBase Reference)
NIST Chemistry ReferenceMethanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry SystemMethanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
Safety Information
Hazard Codes F,Xn,Xi
Risk Statements 11-22-36/37/38-36/38-20-20/21/22-10-52
Safety Statements 16-26-36/37-36/37/39-33-29-7/9
RIDADR UN 3271 3/PG 2
WGK Germany 1
F 21
Autoignition Temperature155 °C
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29225000
ToxicityLD50 orally in Rabbit: > 5000 mg/kg
MSDS Information
ProviderLanguage
N-Dimethoxymethyl-N,N-dimethylamine English
SigmaAldrich English
ACROS English
ALFA English
N,N-Dimethylformamide dimethyl acetal Usage And Synthesis
Chemical Propertiesclear colourless liquid
UsesUsed to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.
Uses1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.
UsesN,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.
DefinitionChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions
General DescriptionEsterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.
Flammability and ExplosibilityHighlyflammable
N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials
Preparation Products5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE-->[1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOL-4-YL]METHANOL-->1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE-->METHYL 4-AMINO-6-INDOLECARBOXYLATE-->Indole-6-carboxylic acid-->2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID-->1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID-->3-BROMOCHROMONE-->3-NITROISONICOTINALDEHYDE-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE-->ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->ETHYL 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE-->5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBONITRILE-->1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE-->(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE-->(1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE-->1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE-->(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL-->5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE-->(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL-->Indole-7-carboxaldehyde-->(1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE-->1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE-->Indole-6-carboxaldehyde-->(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE-->3-NITROBENZO[B]FURAN-5-OL-->ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->6-HYDROXYMETHYLINDOLE-->ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE-->4-(3-Pyridinyl)-2-aminopyrimidine-->4-Aminomethyl-1-methylpyrazole-->1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID-->5-Hydroxyindole-->7-Hydroxyindole
1-(DIMETHOXYMETHYL)PIPERIDINE 1,1-Diisopropoxytrimethylamine PHENACYL-8(TM) REAGENT 1-AZA-3,5-DIMETHYL-4,6-DIOXABICYCLO[3.3.0!OCTANE, 98 1-(DIMETHOXYMETHYL)PYRROLIDINE 1-AZA-4,6-DIOXABICYCLO[3.3.0]OCTANE 2-Dimethylamino-1,3-dioxolane N-FORMYLHEXAMETHYLENEIMINE DIMETHYL ACETAL 1-TERT-BUTOXY-1-METHOXY-TRIMETHYLAMINE N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, [CARBONYL-14C] dimethylformamide dimethyl acetal + tris(dimethylamino)methane N,N-DIMETHYLFORMAMIDE BIS[2-(TRIMETHYL- SILYL)ETHYL] ACETATE N,N-DIMETHYLFORMAMIDE DICYCLOHEXYL ACETAL N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL [688.1.6 REV3] 1,1-Dimethoxy-N,N-dimethylethylamine 1,1-Dibutoxytrimethylamine N,N,5,5-Tetramethyl-1,3-dioxane-2-amine N,N-DIMETHYLFORMAMIDE DIBENZYL ACETAL
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