Tris(hydroxymethyl)nitromethane

Tris(hydroxymethyl)nitromethane Basic information
Product Name:Tris(hydroxymethyl)nitromethane
Synonyms:1,3-Propanediol,2-(hydroxymethyl)-2-nitro-;2-(hydroxymethyl)-2-nitro-3-propanediol;2-(Hydroxymethyl)-2-nitropropanediol;2-hydroxymethyl-2-nitropropane-1,3-diol;3-Propanediol,2-(hydroxymethyl)-2-nitro-1;Cimcool wafers;cimcoolwafers;Isobutylglycerol, nitro-
CAS:126-11-4
MF:C4H9NO5
MW:151.12
EINECS:204-769-5
Product Categories:
Mol File:126-11-4.mol
Tris(hydroxymethyl)nitromethane Structure
Tris(hydroxymethyl)nitromethane Chemical Properties
Melting point 160 °C (dec.) (lit.)
Boiling point 273.1°C (rough estimate)
density 1.5652 (rough estimate)
refractive index 1.4183 (estimate)
solubility H2O: soluble220g/100ml at 20°C
form powder to lump
pka12.32±0.10(Predicted)
color White to Almost white
Water Solubility It is soluble in water.
Merck 14,9753
BRN 742427
LogP0.350 (est)
CAS DataBase Reference126-11-4(CAS DataBase Reference)
NIST Chemistry Reference1,3-Propanediol, 2-(hydroxymethyl)-2-nitro-(126-11-4)
EPA Substance Registry System2-(Hydroxymethyl)-2-nitro-1,3-propanediol (126-11-4)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
RTECS TY7350000
4.10
TSCA Yes
HS Code 29221990
Hazardous Substances Data126-11-4(Hazardous Substances Data)
Toxicitymouse,LD50,intraperitoneal,4gm/kg (4000mg/kg),Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 11(1), Pg. 73, 1977.
MSDS Information
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Tris(hydroxymethyl)nitromethane English
SigmaAldrich English
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Tris(hydroxymethyl)nitromethane Usage And Synthesis
Chemical PropertiesOff-white to orange solid. It crystallizes as white crystals in the mixed solution of ethyl acetate and benzene. Soluble in alcohol, slightly soluble in benzene and other hydrocarbons. Solubility in water (20°C) 220g/100ml.
UsesTris(hydroxymethyl)nitromethane, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is used as a primary and secondary intermediate.
PreparationTris(hydroxymethyl)nitromethane is prepared by the condensation of nitromethane and formaldehyde under basic conditions.
ApplicationTris(hydroxymethyl)nitromethane is a bactericide and slimicide for use in cooling fluids, paper and pulp industry; as a curing agent for certain adhesives; viscositycontrolling agent in cosmetics.To inhibit bacterial growth in circulating industrial water systems, cutting oils, nonprotein glues and sizings.
General DescriptionTris(hydroxymethyl)nitromethane undergoes crosslinking with hexamethylene diisocyanate to form monolithic energetic gels. It is an effective hardener for variety of tannin-based adhesives.
HazardModerate fire risk. Irritant to skin and eyes.
Purification MethodsCrystallise it from CHCl3/ethyl acetate or ethyl acetate/*benzene. It is an acid and a 0.1M solution in H2O has pH 4.5. IRRITANT. [Beilstein 1 H 520.]
Tris(hydroxymethyl)nitromethane Preparation Products And Raw materials
Raw materialsNitromethane-->1-Nitropropan-2-ol-->2-Nitro-1,3-propanediol-->METHANOL WITH FORMALDEHYDE-->1-NITROMETHYLCYCLOHEXANOL
Preparation ProductsTris(hydroxymethyl)aminomethane
TRIS(HYDROXYPROPYL)PHOSPHINE Tris(triphenylphosphine)rhodiu Trisodium methanetrisulfonate Tris(dimethylaminomethyl)phenol 2-METHYL-2-NITRO-1,3-PROPANEDIOL nitrotoluene nitromethane TIMTEC-BB SBB000779 2-METHYL-1,3-PROPANEDIOL 2-Methyl-2-nitropropan-1-ol 2-(HYDROXYMETHYL)-2-NITRO-1,3-PROPANEDIOL = TRIS-(HYDROXYMETHYL)-NITROMETHANE N-Isopropylhydroxylamine trinitromethane 2-(HYDROXYMETHYL)-1,3-PROPANEDIOL TRIS BUFFER SOLUTION PH 8.5, 1 L Tris(hydroxymethyl)nitromethane CARBOXYMETHYLCELLULOSE SODIUM SALT BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE)

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