Parecoxib

Parecoxib Basic information

Product Name:	Parecoxib
Synonyms:	Parecoxib (free);N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide;N-((4-(5-Methyl-3-phenyl-2,3-dihydrooxazol-4-yl)phenyl)sulfonyl)propionaMide;N-(4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)propionaMide;Parecoxib SodiuM IMpurity W;Valdecoxib Impurity J;SC 69124;Valus-P
CAS:	198470-84-7
MF:	C19H18N2O4S
MW:	370.42
EINECS:	803-261-6
Product Categories:	Inhibitors;ZY
Mol File:	198470-84-7.mol

Parecoxib Chemical Properties

Melting point	148.9-151°
density	1.264
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	neat
pka	5.08±0.10(Predicted)
BRN	8640266

Safety Information

Hazard Codes	Xn,N
Risk Statements	63-48/22-51/53
Safety Statements	36/37-61
WGK Germany	3
RTECS	TX1478700

MSDS Information

Parecoxib Usage And Synthesis

Uses	Anti-inflammatory; analgesic (cyclooxygenase COX-2 inhibitor).
Uses	Parecoxib is used in the combination with Telmisartan for the treatment of endometriosis. Parecoxib reduces hippocampal inflammation and improve short-term memory function through the inhibition of COX-2 expression in aged rats after splenectomy.
Definition	ChEBI: An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.

Parecoxib Preparation Products And Raw materials

Raw materials

1,3-Butanedione, 1,2-diphenyl--->5-Methyl-3,4-diphenylisoxazole-->Valdecoxib-->5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL-->Valdecoxib IMpurity F-->2-Phenylacetophenone-->Propionic anhydride-->Benzene-->Benzaldoxime

Nimesulide PARECOXIB SODIUM Ketorolac tromethamine Propofol Ibuprofen FENTANYL 1-(2,6-Dichlorophenyl)-2-indolinone Dezocine Atracurium besylate Esomeprazole Lornoxicam Celecoxib FLURBIPROFEN AXETIL Rivaroxaban Sorafenib Valdecoxib PARECOXIB NA Parecoxib

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