Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Basic information
Product Name:Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
Synonyms:4,5-Bis(2-methoxyethoxy)-2-nitrobenzoic acid ethyl ester;Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;Methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;Erlotinib interMidiate III;Benzoic acid,4,5-bis(2-Methoxyethoxy)-2-nitro-, ethyl ester;Erlotinib Impurity 6;4,5-bis(2-methoxyethoxy)-2-nitrobenzoate;Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate ###179688-26-7
CAS:179688-26-7
MF:C15H21NO8
MW:343.33
EINECS:605-866-9
Product Categories:Erlotinib INTERMEDIATES
Mol File:179688-26-7.mol
Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Structure
Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Chemical Properties
Boiling point 467.8±45.0 °C(Predicted)
density 1.215
storage temp. Refrigerator
solubility DMSO (Slightly), Ethyl Acetate (Slightly)
form Oil
color Yellow
CAS DataBase Reference179688-26-7(CAS DataBase Reference)
Safety Information
MSDS Information
Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Usage And Synthesis
UsesEthyl 4,5-Bis(2-methoxyethoxy)-2-nitrobenzoate is used in the syntheses of 4-(indol-3-yl)quinazolines as epidermal growth factor receptor tyrosine kinase inhibitors. It is also used to prepare Erlotinib hydrochloride (E625000), a useful drug in treatment of non-?small-?cell lung cancer.
Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate Preparation Products And Raw materials
4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Imp.15 Erlotinib Imp.5 Erlotinib Impurity 30 Erlotinib Impurity 38 Erlotinib Impurity 25 Ethyl 3,4-bis(2-methoxyethoxy)benzoate 2-Amino-4,5-bis-(2-methoxy-ethoxy)-benzoic acid >98% METHYL-4,5-DIETHOXY-2-NITROBENZOATE METHYL 5-METHOXY-2-NITROBENZOATE ETHYL 2-AMINO-4,5-DIMETHOXYBENZOATE ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone 4-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER 6-AMINO-3,4-DIETHOXYBENZOIC ACID METHYL 2-AMINO-4,5-DIETHOXYBENZOATE ethyl 2-amino-4-methoxybenzoate METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID

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