Potassium bis(trimethylsilyl)amide

Potassium bis(trimethylsilyl)amide Basic information

Product Name:	Potassium bis(trimethylsilyl)amide
Synonyms:	1,1,1,3,3,3-HEXAMETHYLDISILAZANE POTASSIUM SALT;HEXAMETHYLDISLAZANE POTASSIUM SALT;POTASSIUM BIS(TRIMETHYLSILYL)AMIDE;POTASSIUMHEXAMETHYLDISILAZANE;POTASSIUM HEXAMETHYLDISLAZANE;PotassiumhexamethyldislazaneinTHF;Potassiumbis(trimethylsilyl)amide11%intoluene;Hexamethyldislazanepotassiumsalt12%toluene
CAS:	40949-94-8
MF:	C6H18KNSi2
MW:	199.48
EINECS:	424-100-2
Product Categories:	25mL Sure/Seal Reagents;Aliphatics;Chemical Synthesis;Organic Bases;Organometallic Reagents;Synthetic Reagents;Classes of Metal Compounds;K (Potassium) Compounds (excluding simple potassium salts);Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Typical Metal Compounds;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silazanes;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents)
Mol File:	40949-94-8.mol

Potassium bis(trimethylsilyl)amide Chemical Properties

Melting point	194-195°C
Boiling point	111 °C
density	0.877 g/mL at 25 °C
vapor density	3.2 (vs air)
vapor pressure	54 mm Hg ( 25 °C)
refractive index	1.4920
Fp	45 °F
storage temp.	Refrigerator
solubility	Miscible with terahydrofuran, ether, benzene and toluene.
form	Liquid
Specific Gravity	0.877
color	clear to slightly hazy yellow
Water Solubility	Reacts with water.
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	4006754
CAS DataBase Reference	40949-94-8(CAS DataBase Reference)
EPA Substance Registry System	Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8)

Safety Information

MSDS Information

Potassium bis(trimethylsilyl)amide Usage And Synthesis

Chemical Properties	Colorless to amber solution
Uses	Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.
Uses	Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.
Uses	Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1
Preparation	Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.
General Description	This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".

Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials

Preparation Products

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