epiberberine

epiberberine Basic information

Product Name:	epiberberine
Synonyms:	epiberberine;BerbiniuM;11,12-Dihydro-8,9-dimethoxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium;Epiberberine Chloride;Siberian;8,9-Dimethoxy-11,12-dihydro-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinolin-13-ium
CAS:	6873-09-2
MF:	C20H18NO4+
MW:	336.36122
EINECS:
Product Categories:	chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	6873-09-2.mol

epiberberine Chemical Properties

Melting point	260℃
storage temp.	Amber Vial, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	Orange to Dark Orange

Safety Information

MSDS Information

epiberberine Usage And Synthesis

Uses	Epiberberine Chloride, is a natural bioactive alkaloid, an isomer of Berberine (B318150), an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells.
target	MEK \| ERK \| AMPK \| Akt \| Fatty Acid Synthase \| Raf \| P450 (e.g. CYP17) \| LDL \| HMG-CoA Reductase \| AChE \| BACE \| ROS

epiberberine Preparation Products And Raw materials

Raw materials

12H-Benzo[a]-1,3-benzodioxolo[4,5-g]quinolizine, 11,14-dihydro-8,9-dimethoxy--->Oxyepiberberine-->5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&-->6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE

ARTEMISININ Coptisine chloride Tannic acid berberine Rotundine PILOCARPINE (+)-Camptothecin Rhein Berberine hydrochloride Nitidine chloride MONOCROTALINE BETA-D-GLUCOPYRANOSIDURONIC ACID PHELLODENDRINE CHLORIDE Tetrahydroberberine ISOTETRANDRINE 13,14-Didehydromatridin-15-one Daidzin Palmatine chloride Gallic acid monohydrate

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