2-Hydroxypyridine

2-Hydroxypyridine Basic information
Product Name:2-Hydroxypyridine
Synonyms:1-Hydroxy-2-pyridine;alpha-Pyridone;Pyridone-2;AURORA KA-3075;A-PYRIDONE;TIMTEC-BB SBB004392;a-Hydroxypyridine;1,2-dihydro-2-oxopyridine
CAS:142-08-5
MF:C5H5NO
MW:95.1
EINECS:205-520-3
Product Categories:Others;Pyridines;Pyridine;Pyridines derivates;Building Blocks;C5;Chemical Synthesis;Heterocyclic Building Blocks;(intermediate of benzoxazole);Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;bc0001
Mol File:142-08-5.mol
2-Hydroxypyridine Structure
2-Hydroxypyridine Chemical Properties
Melting point 105-107 °C (lit.)
Boiling point 280-281 °C (lit.)
density 1.39
refractive index 1.5939 (estimate)
Fp 210 °C
storage temp. Sealed in dry,Room Temperature
solubility 450g/l
pka0.75(at 20℃)
form Liquid
color Colorless to yellow to brown, darken on storage with no loss of purity
Water Solubility Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.
BRN 105786
LogP-0.593 (est)
CAS DataBase Reference142-08-5(CAS DataBase Reference)
NIST Chemistry Reference2(1H)-Pyridinone(142-08-5)
EPA Substance Registry System2(1H)-Pyridinone (142-08-5)
Safety Information
Hazard Codes Xi,Xn,T
Risk Statements 36/37/38-40-25
Safety Statements 26-36-37/39-22-45-36/37/39
RIDADR UN2811
WGK Germany 3
RTECS UV1144050
8
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29333990
ToxicityLD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85
MSDS Information
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2-Hydroxypyridine English
SigmaAldrich English
ACROS English
ALFA English
2-Hydroxypyridine Usage And Synthesis
Chemical Propertieswhite to light yellow crystal
Uses2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.
UsesCatalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.
DefinitionChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite.
General Description2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs).
Safety ProfileModerately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.
Purification MethodsDistil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]
FMOC-L-ALA-[3-(6-(3-HYDROXYPYRIDINE))] 2-Chloro-3-Bromo-5-Hydroxypyridine 2-HYDROXY-3-NITROPYRIDINE 6-HYDROXYPYRIDINE-3-SULFONIC ACID 2-Pyridinol-1-oxide 5-CYANO-2-HYDROXYPYRIDINE 6-HYDROXYPYRIDINE-3-SULFONAMIDE 2,6-DIBROMO-3-HYDROXYPYRIDINE 2-methoxy-5-aminopyridine Hydroxy silicone oil QUINOXALIN-5-AMINE 4-BROMO-N-METHYL-1,9-ANTHRAPYRIDONE 6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID 5-BROMO-6-HYDROXYPYRIDINE-3-SULFONIC ACID,5-BROMO-6-HYDROXYPYRIDINE-3-SULPHONIC ACID Chromium picolinate 2,5-Dimethylpyridine 2-Hydroxy-6-methylpyridine-3-carboxylic acid 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID

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