1(3H)-Isobenzofuranone,3-methyl-(9CI)

1(3H)-Isobenzofuranone,3-methyl-(9CI) Basic information

Product Name:	1(3H)-Isobenzofuranone,3-methyl-(9CI)
Synonyms:	1(3H)-Isobenzofuranone,3-methyl-(9CI);3-Butylphthalide Impurity A;Butyphthalide impurity10;3-Methyl-2-benzofuran-1(3H)-one;3-methylisobenzofuran-1(3H)-one;3-methyl-3H-2-benzofuran-1-one;n-Butylphthalide-010;Butylphthalide Impurity 10
CAS:	3453-64-3
MF:	C9H8O2
MW:	148.16
EINECS:
Product Categories:	PHENYL
Mol File:	3453-64-3.mol

1(3H)-Isobenzofuranone,3-methyl-(9CI) Chemical Properties

Boiling point	272-274 °C(Press: 758 Torr)
density	1.175±0.06 g/cm3(Predicted)

Safety Information

MSDS Information

1(3H)-Isobenzofuranone,3-methyl-(9CI) Usage And Synthesis

Uses	3-Methylphthalide is used as a pharmaceutical compound containing butylphthalide and cosolvent for treating ischemic cerebrovascular disease and relieving nerve function impairment after apoplexy.
Synthesis Reference(s)	The Journal of Organic Chemistry, 49, p. 737, 1984 DOI: 10.1021/jo00179a001

1(3H)-Isobenzofuranone,3-methyl-(9CI) Preparation Products And Raw materials

Raw materials	Benzoic acid, 2-[2-(trimethylsilyl)ethynyl]-, ethyl ester-->Benzenemethanol, 2-iodo-α-methyl--->SALOR-INT L480355-1EA-->Benzoic acid, 2-ethenyl- (9CI)-->2-ACETYLBENZALDEHYDE 95-->1-(2'-BROMOPHENYL)-1-HYDROXYETHANE-->methyl 2-ethynylbenzoate-->methyl 2-((trimethylsilyl)ethynyl)benzoate-->2-ETHYLBENZOIC ACID-->carbon monoxide-->2-Acetylbenzoic acid-->Acetaldehyde-->2-Bromobenzoic acid
Preparation Products	2-ETHYLBENZONITRILE

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