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| | 1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- Basic information |
| | 1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 16 mg/ml; DMSO: 0.16 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid |
| | 1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- Usage And Synthesis |
| Description | 1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity.1,2 | | References | 1. Castillo, S.S., Brognard, J., Petukhov, P.A., et al. Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues Cancer Res. 64(8),2782-2792(2004).
2. Memmott, R.M., Gills, J.J., Hollingshead, M., et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non-small cell lung cancer cells Cancer Res. 68(2),580-588(2008). |
| | 1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- Preparation Products And Raw materials |
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