Hydrocortisone

Hydrocortisone Basic information

Product Name:	Hydrocortisone
Synonyms:	hydrocortisone aceponate;[(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;[(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;propionic acid [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester;Hydrocortisone 17-Propionate 21-Acetate;Hydrocortisonepropylacetate;Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11β)-;Efficort
CAS:	74050-20-7
MF:	C26H36O7
MW:	460.56
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API
Mol File:	74050-20-7.mol

Hydrocortisone Chemical Properties

Melting point	144-146°C
density	1.23±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Pale Beige

Safety Information

MSDS Information

Hydrocortisone Usage And Synthesis

Description	Hydrocortisone aceponate is the 17-a-propionate derivative of hydrocortisone-21-acetate. Its is reportedly significantly superior to the latter in the treatment of dermatoses of varying severity.
Chemical Properties	White to Off-White Solid
Originator	Beiersdorf (W.Germany)
Uses	A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid.
Definition	ChEBI: Hydrocortisone aceponate is a corticosteroid hormone.
Brand name	Retef

Hydrocortisone Preparation Products And Raw materials

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