|
| | Basifungin Basic information |
| Product Name: | Basifungin | | Synonyms: | Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-];LY-295337;Aureobasidin A (9CI);Aureobasidin A (AbA);Basifungin;aureobasidin A;Cyclo[L-alloisoleucyl-N-methyl-L-valyl-L-leucyl-N,3-dimethyl-L-threonyl-(2R,3R)-2-hydroxy-3-methylpentanoyl-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl];Basifungin/Aureobasidin A | | CAS: | 127785-64-2 | | MF: | C60H92N8O11 | | MW: | 1101.42 | | EINECS: | | | Product Categories: | | | Mol File: | 127785-64-2.mol |  |
| | Basifungin Chemical Properties |
| Boiling point | 1229.1±65.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, protect from light | | solubility | DMSO : 100 mg/mL (90.79 mM; Need ultrasonic) | | pka | 13.35±0.70(Predicted) |
| | Basifungin Usage And Synthesis |
| Uses | Basifungin, also known as aureuobacidin A, is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. This may inhibit fungal cell growth. | | Definition | ChEBI: Basifungin is a cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus Aureobasidium pullulans R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml). | | Clinical Use | Aureobasidin A is a cyclic depsipeptide that is produced byfermentation in cultures of Aureobasidium pullulan.Aureobasidin A acts as a tight-binding noncompetitive inhibitorof the enzyme inositol phosphorylceramide synthase(IPC synthase), which is an essential enzyme for fungalsphingolipid biosynthesis. A unique structural feature of theaureobasidins is the N-methylation of four of seven amide nitrogenatoms. The lack of tautomerism dictated by N-methylationmay contribute to forming a stable solution conformerthat is shaped somewhat like an arrowhead, the presumed biologicallyactive conformation of aureobasidin-A.The pradimycins and benanomycins are naphthacenequinonesthat bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi. Both demonstrate good in vitro and in vivo activity againstCandida spp. and C. neoformans clinical isolates. |
| | Basifungin Preparation Products And Raw materials |
|
