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| | Irsogladine maleate Basic information |
| Product Name: | Irsogladine maleate | | Synonyms: | 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate;2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate;3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1);gaslon;mn-1695;2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate;Irsogladin maleate;Gaslon N | | CAS: | 84504-69-8 | | MF: | C13H11Cl2N5O4 | | MW: | 372.16 | | EINECS: | | | Product Categories: | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 84504-69-8.mol |  |
| | Irsogladine maleate Chemical Properties |
| Melting point | 181-182°C | | storage temp. | Inert atmosphere,Room Temperature | | Water Solubility | Insoluble in water | | solubility | DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) | | form | White crystalline powder. | | color | White to Almost white | | Merck | 14,5102 | | CAS DataBase Reference | 84504-69-8(CAS DataBase Reference) |
| RTECS | XY5930000 | | HS Code | 2933.69.6050 | | Toxicity | LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474) |
| | Irsogladine maleate Usage And Synthesis |
| Description | Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram . | | Chemical Properties | White Solid | | Uses | An anti-ulcer drug. Potent PDE4 inhibitor | | Uses | antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication | | Definition | ChEBI: Irsogladine maleate is a dichlorobenzene. | | Biological Activity | Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis. |
| | Irsogladine maleate Preparation Products And Raw materials |
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