Isochlorogenic acid A

Isochlorogenic acid A Basic information
Product Name:Isochlorogenic acid A
Synonyms:3,5-Dicaffeoylquinic acid;Isochlorogenic acid A;Isochlorogenic acid A,3,5-Dicaffeoylquinic acid;3α,5β-Bis[[1-oxo-3-(3,4-dihydroxyphenyl)-2-propenyl]oxy]-1α,4α-dihydroxycyclohexane-1-carboxylic acid;1α,4α-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid;1β,4β-Dihydroxy-3β,5α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1α-cyclohexanecarboxylic acid;1β,4β-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]cyclohexane-1-carboxylic acid;1β,4β-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid
CAS:2450-53-5
MF:C25H24O12
MW:516.46
EINECS:
Product Categories:The group of Chlorogenic acid;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Aromatic Phenols
Mol File:2450-53-5.mol
Isochlorogenic acid A Structure
Isochlorogenic acid A Chemical Properties
Melting point >175°C (dec.)
Boiling point 826.2±65.0 °C(Predicted)
density 1?+-.0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO (Slightly), Methanol (Slightly)
pka3.54±0.50(Predicted)
form Off-white to yellow/brown crystalline solid.
color Off-White to Pale Yellow
Stability:Hygroscopic
InChIKeyKRZBCHWVBQOTNZ-PSEXTPKNSA-N
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS GU8403966
HS Code 29189900
MSDS Information
Isochlorogenic acid A Usage And Synthesis
Description3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants. It has antioxidant, anti-inflammatory, and antiviral biological activities. 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM). It inhibits HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml). In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).
UsesIsochlorogenic Acid A is a phenolic compound shown to provide protection against oxidative stress cells. DNA protective agent.
DefinitionChEBI: 3,5-di-O-caffeoyl quinic acid is a carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities. It has a role as a metabolite, a hepatoprotective agent and an antineoplastic agent. It is a cyclitol carboxylic acid and a carboxylic ester. It is functionally related to a (-)-quinic acid and a trans-caffeic acid.
Isochlorogenic acid A Preparation Products And Raw materials
Pentyl cinnamate Dicaffeoylquinic acid Ethyl 2-(Chlorosulfonyl)acetate ISOCHLOROGENIC ACID Ascoric Acid CYCLOHEXYL CINNAMATE Stearic acid Dibenzoyltartaric acid Folic acid Quinic acid Dibutyryl adenosine cyclophosphate calcium Diethyl succinosuccinate Chlorogenic Acid (Honegsukle Flower extract) Isochlorogenic acid A Cryptochlorogenic acid ISOCHLOROGENIC ACID(PLEASE CALL)(P) EPA Citric acid

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