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Quinapril hydrochloride

Quinapril hydrochloride Basic information
Product Name:Quinapril hydrochloride
Synonyms:Acupril;Korec;Korectic;Quinazil;ccupril;(3S-(2(R*(R*)),3R*))-2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride;(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride;(3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid hydrochloride
CAS:82586-55-8
MF:C25H31ClN2O5
MW:474.98
EINECS:620-479-5
Product Categories:Accupril;Intermediates & Fine Chemicals;Active Pharmaceutical Ingredients;APIs;Pharmaceuticals;Steroids
Mol File:82586-55-8.mol
Quinapril hydrochloride Structure
Quinapril hydrochloride Chemical Properties
Melting point 120-130°C
alpha D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls)
storage temp. 2-8°C
solubility H2O: >10mg/mL
form solid
color white
CAS DataBase Reference82586-55-8(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS NW7176000
HS Code 2933492250
Hazardous Substances Data82586-55-8(Hazardous Substances Data)
ToxicityFreely sol in aq solvents. LD50 in male, female mice, rats (mg/kg): 1739, 1840, 4280, 3541 orally; 504, 523, 158, 107 i.v. (Kaplan, 1989)
MSDS Information
Quinapril hydrochloride Usage And Synthesis
Chemical PropertiesWhite Crystalline Solid
UsesAntihypertensive;Dopamine receptor agonist
UsesQuinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
UsesQuinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.
DefinitionChEBI: Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+).
Brand nameAccupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) .
General DescriptionQuinapril hydrochloride,(S)-[(S)-N-[(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hydrochloride(Acuretic), forms the diacid quinaprilate in thebody. It is more potent than captopril and equipotent to theactive form of enalapril.
Biochem/physiol ActionsQuinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.
Quinapril hydrochloride Preparation Products And Raw materials
Preparation ProductsQuinapril-->DRKDCOUMTGAAKG-IGKWTDBASA-N
1,1'-Carbonyldiimidazole Betaine Quinapril Carbonyl iron powder Benazepril hydrochloride Topotecan hydrochloride Quinapril benzyl ester maleate ALTRENOGEST QUINAPRIL-D5, HYDROCHLORIDE CARBONYL SULFIDE Glycine NICKEL CARBONYL Triprolidine hydrochloride Mefloquine hydrochloride Lithium diisopropylamide QUINAPRIL Quinapril hydrochloride AMINO ACIDS
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