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| | (+)-PINORESINOL Basic information |
| Product Name: | (+)-PINORESINOL | | Synonyms: | (+)-PINORESINOL;(-)-4,4'-[[(3aα,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan]-1α,4α-diyl]bis(2-methoxyphenol);(3aS,6aS)-3a,4,6,6a-Tetrahydro-3β,6β-bis(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan;(3R,3aβ,6aβ)-3β,6β-Bis(3-methoxy-4-hydroxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan;2-Methoxy-4-[(1R)-4α-(3-methoxy-4-hydroxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan-1α-yl]phenol;4,4'-[[(3aα,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan]-1α,4α-diyl]bis(2-methoxyphenol);(1S)-1β,4β-Bis(4-hydroxy-3-methoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan;(1β,5β)-2β,6β-Bis(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane | | CAS: | 487-36-5 | | MF: | C20H22O6 | | MW: | 358.39 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 487-36-5.mol |  |
| | (+)-PINORESINOL Chemical Properties |
| Melting point | 112 °C | | Boiling point | 556.5±50.0 °C(Predicted) | | density | 1.385 g/cm3 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: ≥6mg/mL | | pka | 9.54±0.35(Predicted) | | form | Solid | | color | white to tan | | LogP | 1.591 (est) |
| | (+)-PINORESINOL Usage And Synthesis |
| Description | (+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. It is an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 μM in Baker’s yeast and rat small intestine, respectively). (+)-Pinoresinol scavenges ABTS , but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; ), radicals in cell-free assays (IC50s = 13.43 and >200 μg/ml, respectively). It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 μM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 μM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 μM). | | Uses | (+)-Pinoresinol is a lignan found in olive oil and in other plants. This phenolic compound was reported to have antioxidant and anticancer potential. | | Definition | ChEBI: An enantiomer of pinoresinol having (+)-1S,3aR,4S,6aR-configuration. |
| | (+)-PINORESINOL Preparation Products And Raw materials |
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