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| | Ivabradine hydrochloride Basic information |
| Product Name: | Ivabradine hydrochloride | | Synonyms: | Ivabradine HCl;Ivabradine hydrochloride;3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;Ivabradine hydrochloride, >=99%;IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR;Ivabradine hydrochloride, 98%, a If inhibitor;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride;Corlentor | | CAS: | 148849-67-6 | | MF: | C27H37ClN2O5 | | MW: | 505.05 | | EINECS: | 638-798-3 | | Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API;Cardiovascular APIs;Inhibitors | | Mol File: | 148849-67-6.mol |  |
| | Ivabradine hydrochloride Chemical Properties |
| Melting point | 193-196?C | | alpha | 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO) | | storage temp. | 2-8°C | | solubility | H2O: ≥5mg/mL (warmed) | | form | powder | | color | white to beige | | optical activity | [α]/D +5 to +9°, c = 1 in DMSO | | Merck | 14,5247 | | InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N | | SMILES | C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r| | | CAS DataBase Reference | 148849-67-6(CAS DataBase Reference) |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | HS Code | 2933.79.1500 |
| | Ivabradine hydrochloride Usage And Synthesis |
| Description | In an effort to develop angina agents without the unwanted negative
inotropic and hypotensive effects associated with b-adrenergic blockers and
calcium channel blockers, a new class of heart-rate reducing compounds that act
specifically on the sinoatrial (SA) node has been explored. These bradycardic
agents interact directly with the pacemaking cell of the SA node and the hyperpolarization-
activated If , the primary pacemaking current. Ivabradine has
evolved as a specific inhibitor of If current through its contact with f-channels on
the intracellular side of the plasma membrane. As a consequence, ivabradine
reduces the speed of diastolic depolarization and decreases heart rate. It has been
approved for the treatment of chronic stable angina and provides a viable
alternative to patients with a contraindication or intolerance of b-blockers. Evaluation
is also underway for the potential treatment of ischemic heart disease.
Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If
current ranged from 6% (0.03 mM) – 80% (10 mM).
. | | Chemical Properties | White to Off-White Solid | | Originator | Servier (France) | | Uses | Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT). | | Uses | Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent | | Uses | angina therapeutic | | Uses | Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal | | Definition | ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure. | | Brand name | Procoralan | | Biochem/physiol Actions | Ivabradine is used to treat chronic heart failure. | | Clinical Use | Symptomatic treatment of chronic stable angina pectoris
in patients with sinus rhythm
Treatment of mild to severe chronic heart failure | | storage | Store at -20°C |
| | Ivabradine hydrochloride Preparation Products And Raw materials |
| Raw materials | 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride-->3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one-->(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride |
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