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| | rosoxacin Basic information |
| Product Name: | rosoxacin | | Synonyms: | 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylic acid;Acrosoxacin;PD-107522;Win-35213;1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid;1-Ethyl-4-oxo-7-(4-pyridyl)-1,4-dihydroquinoline-3-carboxylic Acid;rosoxacin;3-Quinolinecarboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)- | | CAS: | 40034-42-2 | | MF: | C17H14N2O3 | | MW: | 294.3 | | EINECS: | 254-758-4 | | Product Categories: | | | Mol File: | 40034-42-2.mol |  |
| | rosoxacin Chemical Properties |
| Melting point | 290° | | Boiling point | 500.8±50.0 °C(Predicted) | | density | 1.317±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF (Very Slightly) | | form | Solid | | pka | 6.48±0.41(Predicted) | | color | Light Beige to Beige |
| | rosoxacin Usage And Synthesis |
| Uses | Antibacterial. | | Definition | ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has be
n used for treating urinary tract infections and certain sexually transmitted diseases. | | Brand name | Roxadyl (Sterling Winthrop). | | Pharmacokinetics | A single oral dose of 300 mg produces a mean peak plasma concentration of 4–5 mg/L at about 2–4 h, with an apparent elimination half-life of about 6 h. Elimination in the urine is partly as the N-oxide metabolite and the glucuronide of this metabolite.
Side effects are those common to quinolones, notably gastrointestinal tract and CNS disturbances. About 50% of patients treated with single oral doses of 100–400 mg developed dizziness, drowsiness, altered visual perception and other CNS effects.
It is effective as single-dose treatment of patients with urethral and anorectal gonorrhea, but coexistent C. trachomatis infection is not eliminated from most patients and postgonococcal urethritis develops in up to 30%. |
| | rosoxacin Preparation Products And Raw materials |
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