ChemicalBook Product Catalog Chemical Reagents Organic reagents Hydrazone Ambazone

Ambazone

Ambazone Basic information
Product Name:Ambazone
Synonyms:1,4-Benzoquinone guanylhydrazone thiosemicarbazone;Faringosept;Inversal;((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-guanidin thiosemicarbazone;((4-oxo-2,5-cyclohexadien-1-ylidene)amino)guanidine thiosemicarbazone;1-amidinohydrazono-4-thiosemicarbazono-2,5-cyclohexadiene;ambazon;anginon
CAS:539-21-9
MF:C8H11N7S
MW:237.28
EINECS:208-713-0
Product Categories:Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:539-21-9.mol
Ambazone Structure
Ambazone Chemical Properties
Melting point 195°C (rough estimate)
Boiling point 160°C (rough estimate)
density 1.2732 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Red to Very Dark Brown
Stability:Very Hygroscopic
EPA Substance Registry SystemHydrazinecarbothioamide, 2-[4-[(aminoiminomethyl)hydrazono]-2,5-cyclohexadien-1-ylidene]- (539-21-9)
Safety Information
MSDS Information
Ambazone Usage And Synthesis
OriginatorAmbazone,Generic
UsesAmbazone is a benzoquidine diimine derivative useful as animal growth substance.
DefinitionChEBI: Ambazone is a hydrazone.
Manufacturing ProcessTo a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water. The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L of water at 100°C. The solution is filtered and added to an aqueous ammonium solution. Blue residue of p-benzoquinone amidinohydrazone thiosemicarbazone is filtered and dried, melting point 188°C (decomp.).
Therapeutic FunctionAntiseptic
Ambazone Preparation Products And Raw materials
Raw materialsNitric acid-->thiosemicarbazide
ambazone 82-80 1,4-HEXADIENE N,N'-Diethylthiourea Difurazone Bis(cyclohexanone)oxaldihydrazone (2Z)-2-((4Z)-4-[(AMINOCARBONOTHIOYL)HYDRAZONO]CYCLOHEXA-2,5-DIEN-1-YLIDENE)HYDRAZINECARBOXIMIDAMIDE NITRATE Hydrazodicarbothioamide Dithizone Ambazone hydrate PHENYL VALERATE 1-PHENYL-2-THIOUREA 2-Cyclohexen-1-one 2-(2-Aminoethyl)isothiourea dihydrobromide [4-(amidinohydrazono)cyclohexa-2,5-dienal] semicarbazone Ambazone Impurity Ambazone Impurity 2 3-(4-oxocyclohexa-2,5-dien-1-ylidene)carbazamidine Ambazone Impurity 4
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