cloprednol

cloprednol Basic information
Product Name:cloprednol
Synonyms:(11β)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione;Cloprednole;6-Chloro-11β,17,21-trihydroxypregna-1,4,6-triene-3,20-dione;RS-4691;Syntestan;cloprednol;Cloradryn;Novacort
CAS:5251-34-3
MF:C21H25ClO5
MW:392.876
EINECS:2260526
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:5251-34-3.mol
cloprednol Structure
cloprednol Chemical Properties
Melting point >125°C (dec.)
Boiling point 600.3±55.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Ethyl Acetate (Slightly), Methanol (Slightly)
pka12.30±0.70(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
cloprednol Usage And Synthesis
OriginatorSyntestan,Syntex,W. Germany,1980
UsesA systematic corticosteroid. Anti-inflammatory.
DefinitionChEBI: Cloprednol is a 21-hydroxy steroid.
Manufacturing ProcessA mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted with ether. The solution was successively washed with water, 5% sodium carbonate solution and water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness under reduced pressure. Chromatographic purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6- pregnatriene-11β,17α,21-triol-3,20-dione.
Therapeutic FunctionGlucocorticoid
cloprednol Preparation Products And Raw materials
Raw materialsChloranil
Dexamethasone 21-phosphate disodium salt Hydrocortisone sodium succinate Triptorelin Isoproterenol Dexamethasone CHLOROPROPANOL, MIXED ISOMERS Clomifene Diprophylline Tamoxifen DODECENYL CHLORIDE 1-CHLORO-3,3-DIMETHYLPENTANE 2-Chloroundec-1-ene 10-CHLORO-1-DECANOL CIS-9, TRANS-11-TETRADECADIENOL cloprednol delmadinone 2-Chlorododec-1-ene 3-Chloro-2-methylpropene

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