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| | Aclatonium napadisilate Basic information |
| Product Name: | Aclatonium napadisilate | | Synonyms: | 2-(2-acetyloxypropanoyloxy)ethyl-[2-[2-(2-acetyloxypropanoyloxy)ethyl-dimethyl-ammonio]ethyl]-dimethyl-azanium naphthalene-1,5-disulfonate;aclatonium napadisilate;Aclatonium;1,5-Naphthalenedisulfonic acid, ion(2-), bis[2-[2-(acetyloxy)-1-oxopropoxy]-N,N,N-trimethylethanaminium] (9CI);Abovis;aclatonium napadisylate;Ethanaminium, 2-[2-(acetyloxy)-1-oxopropoxy]-N,N,N-trimethyl-, 1,5-naphthalenedisulfonate (2:1);TM 723 | | CAS: | 55077-30-0 | | MF: | C30H44N2O14S2 | | MW: | 720.80536 | | EINECS: | 1592732-453-0 | | Product Categories: | | | Mol File: | 55077-30-0.mol |  |
| | Aclatonium napadisilate Chemical Properties |
| Melting point | 189-191° | | solubility | DMSO (Slightly), Water (Slightly) | | form | Solid | | color | Crystals | | Stability: | Hygroscopic |
| Toxicity | LD50 in mice: 15 g/kg orally, 826 mg/kg s.c. (Miura); in dogs: >10 g/kg orally (Takai) |
| | Aclatonium napadisilate Usage And Synthesis |
| Originator | Abovis ,Toyama ,Japan ,1981 | | Uses | Aclatonium Napadisilate is a useful bioactive therapeutic agent for autoimmune diseases. A cholinergic agonist. | | Manufacturing Process | 5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of
acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto.
This mixture was refluxed for 3 hours. The resulting reaction mixture was
allowed to stand at room temperature while cooling to precipitate the desired
product crystals, which were collected by filtration. 5.5 g (76% yield) of the
desired product having a melting point of 189°C to 191°C were obtained. | | Therapeutic Function | Cholinergic | | Safety Profile | Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent. |
| | Aclatonium napadisilate Preparation Products And Raw materials |
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