Isobutyric anhydride

Isobutyric anhydride Basic information
Product Name:Isobutyric anhydride
Synonyms:Isobutyric anhydride, distilled;#niso-Butyric anhydride;Bis(2-methylpropanoic)anhydride;Bis(2-methylpropionic)anhydride;Bis(isobutyric)anhydride;Di(isobutyric acid)anhydride;Diisobutyric anhydride;(iso-C3H7CO)2O
CAS:97-72-3
MF:C8H14O3
MW:158.2
EINECS:202-603-6
Product Categories:Organics;1
Mol File:97-72-3.mol
Isobutyric anhydride Structure
Isobutyric anhydride Chemical Properties
Melting point -56 °C (lit.)
Boiling point 182 °C (lit.)
density 0.954 g/mL at 25 °C (lit.)
vapor density 5.45 (vs air)
vapor pressure 10 mm Hg ( 67 °C)
refractive index n20/D 1.406(lit.)
Fp 152 °F
storage temp. Store below +30°C.
form Liquid
color Clear colorless
explosive limit1.09%, 87°F
Water Solubility decomposes
Sensitive Moisture Sensitive
BRN 386267
Exposure limitsACGIH: TWA 10 ppm
NIOSH: TWA 10 ppm(30 mg/m3); STEL 15 ppm(45 mg/m3)
LogP1.1 at 25℃
CAS DataBase Reference97-72-3(CAS DataBase Reference)
NIST Chemistry ReferencePropanoic acid, 2-methyl-, anhydride(97-72-3)
EPA Substance Registry SystemIsobutyric anhydride (97-72-3)
Safety Information
Hazard Codes C
Risk Statements 34-21/22
Safety Statements 26-36/37/39-45
RIDADR 2922
WGK Germany 3
RTECS NQ5550000
13-21
Autoignition Temperature624 °F
TSCA Yes
HS Code 2915 90 70
HazardClass 8
PackingGroup II
Hazardous Substances Data97-72-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 266 mg/kg LD50 dermal Rabbit 475 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Isobutyric anhydride Usage And Synthesis
Chemical Propertiesclear colorless liquid
UsesChemical intermediate.
UsesIsobutyric anhydride was used in the synthesis of 4-O-isobutyryl derivative via reaction with octyl β-D-glucopyranoside in the presence of C2-symmetric chiral 4-pyrrolidinopyridine as a catalyst.
DefinitionChEBI: An acyclic carboxylic anhydride of isobutyric acid. Metabolite observed in cancer metabolism.
General DescriptionA colorless liquid. Flash point 139°F. Burns skin and eyes. Vapors are heavier than air.
Air & Water ReactionsFlammable. Reacts exothermically with water or moisture-containing materials to form isobutyric acid.
Reactivity ProfileIsobutyric anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with a cids, strong oxidizing agents, alcohols, amines, and bases.
HazardStrong irritant to tissue.
Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
5,7,7-TRIMETHYL-3,6-DIOXABICYCLO[3.2.2]NONANE-2,4-DIONE Cantharidin 2-METHYLBUTANOIC ANHYDRIDE AKOS BBS-00006055 2-PHENYLBUTYRIC ACID ANHYDRIDE 1-BROMO-5,8,8-TRIMETHYL-3-OXABICYCLO[3.2.1]OCTANE-2,4-DIONE (1R,3S)-(-)-CAMPHORIC ANHYDRIDE AURORA KA-3050 5,8,8-TRIMETHYL-2,4-DIOXO-3-OXABICYCLO[3.2.1]OCTANE-1-CARBOXYLIC ACID (S)-(+)-2-METHYLBUTYRIC ANHYDRIDE AKOS BBS-00006053 (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE 2-ETHYLBUTYRIC ANHYDRIDE AKOS BBS-00006054 Isobutyric anhydride DL-CAMPHORIC ANHYDRIDE 8-(IODOMETHYL)-1,8-DIMETHYL-3-OXABICYCLO[3.2.1]OCTANE-2,4-DIONE TRIMETHYLACETIC ANHYDRIDE

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