Dibromomethane

Dibromomethane Basic information
Product Name:Dibromomethane
Synonyms:DIBROMOMETHANE FOR SYNTHESIS;1,1-dibroMoMethane;Dibromomethane, Stabilized with 50ppm BHT;dopamine beta-hydroxylase (dopamine beta-monooxygenase);DIBROMOMETHANE, 1000MG, NEAT;DIBROMOMETHANE, 99+%;DIBROMOMETHANE, 1X1ML, MEOH, 2000UG/ML;DIBROMOMETHANE, 1X1ML, MEOH, 5000UG/ML
CAS:74-95-3
MF:CH2Br2
MW:173.83
EINECS:200-824-2
Product Categories:Alkyl;Building Blocks;Analytical Chemistry;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks;Standard Solution of Volatile Organic Compounds for Water & Soil Analysis;Standard Solutions (VOC);Alpha Sort;BromoVolatiles/ Semivolatiles;Chemical Class;D;DAlphabetic;DIA - DIC;Pharmaceutical Intermediates;Organics;alpha,omega-Bifunctional Alkanes;alpha,omega-Dibromoalkanes;Monofunctional & alpha,omega-Bifunctional Alkanes;Halogenated;Dibenzoylmethane
Mol File:74-95-3.mol
Dibromomethane Structure
Dibromomethane Chemical Properties
Melting point -52 °C
Boiling point 96-98 °C(lit.)
density 2.477 g/mL at 25 °C(lit.)
vapor density 6.05 (vs air)
vapor pressure 34.9 mm Hg ( 20 °C)
refractive index n20/D 1.541(lit.)
Fp 96-98°C
storage temp. Store below +30°C.
solubility 11.7g/l
form Liquid
color Clear colorless to slightly brown
Water Solubility 0.1 g/100 mL (20 ºC)
Merck 14,6061
BRN 969143
Stability:Stable. Incompatible with strong oxidizing agents, aluminium, magnesium. Reacts violently with potassium.
CAS DataBase Reference74-95-3(CAS DataBase Reference)
NIST Chemistry ReferenceMethane, dibromo-(74-95-3)
EPA Substance Registry SystemDibromomethane (74-95-3)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 20-52/53-39/23/24/25-23/24/25-11
Safety Statements 24-61-45-36/37-16-7
RIDADR UN 2664 6.1/PG 3
WGK Germany 2
RTECS PA7350000
TSCA Yes
HS Code 2903 39 15
HazardClass 6.1
PackingGroup III
Hazardous Substances Data74-95-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 108 mg/kg LD50 dermal Rabbit > 4000 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Dibromomethane Usage And Synthesis
DescriptionDibromomethane is a member of the class of bromomethanes that is methane substituted by two bromo groups. It is produced by marine algae. It has a role as a marine metabolite and an algal metabolite. It is a member of bromomethanes and a bromohydrocarbon.
Chemical Propertiescolourless liquid
Chemical PropertiesDibromomethane is a colorless liquid with a sweet, pleasant odor.
UsesOrganic synthesis, solvent.
UsesDibromomethane is used as solvent in organic synthesis. It acts as an intermediate in the manufacture of specialty chemicals, agrochemicals and pharmaceuticals. It is useful as extractant and utilized for the determination of 5-nitroimidazoles (5-NDZ) in environmental waters. It is involved in the convertion of catechols to their methylenedioxy derivatives.
DefinitionChEBI: A member of the class of bromomethanes that is methane substituted by two bromo groups. It is produced by marine algae.
General DescriptionA colorless liquid with a pleasant odor. Insoluble in water and denser than water. May be toxic by ingestion. Used as a solvent and as a motor fuel.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileHalogenated aliphatic compounds, such as Dibromomethane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals (potassium), and epoxides.
Health HazardINHALATION: Anesthetic effects, nausea and drunkenness. CONTACT WITH SKIN AND EYES: Skin irritation of eyes and nose.
Fire HazardSpecial Hazards of Combustion Products: Dissociation products generated in a fire may be irritating or toxic.
ToxicologyA poison. Moderately toxic by subcutaneous route. Mdly toxic by inhalation. Mutation data reported. mxtures with potassium explode on light impact. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES
HazardIn laboratory studies, animals experienced CNS depression at 2400-2800 ppm and liver and kidney damage after repeated exposures to 1000 ppm. Dichloromethane rarely causes hepatotoxicity unless exposure is extremely heavy or agent ingested. If left on clothes, it may cause reddening of skin; may have effects on the nervous system and blood, causing impaired functions, carboxyhemoglobinemia, and lowering of consciousness; chronic exposure may cause liver and kidney effects; an irritant; harmful by inhalation; a simple asphyxiant; may cause blood disorders, cardiac irregularities, and CNS depression;
SynthesisDibromomethane is synthesized commercially from dichloromethane via bromochloromethane:
6 CH2Cl2  + 3 Br2  + 2 Al  →  6 CH2BrCl  +  2 AlCl3
CH2Cl2  + HBr  →  CH2BrCl  +  HCl
The latter route requires aluminium trichloride as a catalyst. The bromochloromethane product from either reaction can further react in a similar manner:
6 CH2BrCl  + 3 Br2  + 2 Al  →  6 CH2Br2  +  2 AlCl3
CH2BrCl  + HBr  →  CH2Br2  +  HCl
In the laboratory, it is synthesized from bromoform:
CHBr3 + Na3AsO3 + NaOH → CH2Br2 + Na3AsO4 + NaBr
using sodium arsenite and sodium hydroxide.
Another way is to synthesize it from diiodomethane and bromine. 
Potential ExposureMethylene bromide is used as a solvent and as a chemical intermediate.
ShippingUN2664 Dibromomethane, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
IncompatibilitiesMixture with potassium forms a shocksensitive explosive. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, sodium amide, strong acids, strong bases, alkaline earth metals, aluminum, magnesium. The substance decomposes on contact with hot surfaces producing hydrogen bromide
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal
CHLORODIBROMOMETHANE Methylene Chloride Methylene Blue Clidinium bromide Bromofluoromethane Sodium bromate CI NO 50205 DIBROMOACETONITRILE Bromochloromethane Ethidium bromide Bromodiphenylmethane Dibromomethane 4,4'-Diphenylmethane diisocyanate DIBROMODIFLUOROMETHANE Bromoform Methyl bromide Tribromoacetic acid BROMOTRIFLUOROMETHANE

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