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| | Thiazole Basic information |
| | Thiazole Chemical Properties |
| Melting point | -33°C | | Boiling point | 117-118 °C (lit.) | | density | 1.2 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.538(lit.) | | FEMA | 3615 | THIAZOLE | | Fp | 72 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 2.44(at 20℃) | | form | Liquid | | color | Clear colorless to yellow | | Specific Gravity | 1.200 | | Odor | at 0.10 % in propylene glycol. pyridine nutty meaty | | Odor Type | fishy | | Water Solubility | slightly soluble | | Sensitive | Air & Light Sensitive | | Merck | 14,9307 | | JECFA Number | 1032 | | BRN | 103852 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | LogP | 0.44 | | CAS DataBase Reference | 288-47-1(CAS DataBase Reference) | | NIST Chemistry Reference | Thiazole(288-47-1) | | EPA Substance Registry System | Thiazole (288-47-1) |
| Hazard Codes | Xn,F | | Risk Statements | 10-22-37/38-41 | | Safety Statements | 16-26-39 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | RTECS | XJ1290000 | | F | 8-10-23 | | TSCA | T | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29341000 |
| | Thiazole Usage And Synthesis |
| Chemical Properties | colourless or pale yellow liquid with a disgusting smell | | Chemical Properties | Thiazole has a green, sweet, nutty, tomato note. | | Occurrence | Reported found in roasted chicken, chicken fat, boiled and cooked beef, grilled and roasted beef, pork liver, beer, cognac and other types of grape brandy, rum, coffee, roasted barley, roasted filbert, roasted peanut, soybean, popcorn, oat products, rice bran, buckwheat, malt, wort, dried bonito, crab, crayfish, Chinese quince and other natural sources. | | Uses | Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignard?s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium. | | Uses | Thiazoles were used to create novel recognition motifs for interaction with divalent and trivalent metal ions in siderophores or antibiotics. | | Uses | Organic synthesis of fungicides, dyes, and rubber
accelerators. | | Definition | A colorless volatile liquid, a beterocyclic compound with a five-membered ring
containing three carbon atoms, one nitrogen atom, and one sulfur atom. It resembles PYRIDINE in its reactions. | | Definition | thiazole: A heterocyclic compound containing a five-membered ringwith sulphur and nitrogen heteroatoms, C3SNH3. A range of thiazoledyes are manufactured containingthis ring system. | | Aroma threshold values | Detection: 3.1 ppm | | General Description | Colorless or pale yellow liquid with a foul odor. | | Air & Water Reactions | Slightly water soluble. | | Reactivity Profile | Thioisocyanates, such as Thiazole, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. |
| | Thiazole Preparation Products And Raw materials |
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