ChemicalBook Product Catalog Biochemical Engineering Polypeptide (R)-4-Benzyl-2-oxazolidinone

(R)-4-Benzyl-2-oxazolidinone

(R)-4-Benzyl-2-oxazolidinone Basic information
Product Name:(R)-4-Benzyl-2-oxazolidinone
Synonyms:4-benzyl-2-0xazolidinone;(R)-4-BENZYL-2-OXAZOLIDINONE HPLC 99+%;(R)-4-BENZYL-2-OXAZOLIDINONE 98.0%;(4R)-4-(Phenylmethyl)-1,3-oxazolidin-2-one;(4R)-4-(Phenylmethyl)-2-oxazolidinone;(4R)-Benzyloxazolidin-2-one;(4R)-Phenylmethyl-2-oxazolidinone;(R)-(+)-4-BENZYL-2-OXAZOLIDINONE FOR SYN
CAS:102029-44-7
MF:C10H11NO2
MW:177.2
EINECS:600-264-2
Product Categories:Asymmetric Synthesis;Chiral Auxiliaries;Peptide;Aromatics;Chiral Reagents;Heterocycles;Chiral Compounds;chiral;Asymmetric Synthesis;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Chiral chemicals;Ketone;Oxazolidinone;Oxazolidinone Derivatives
Mol File:102029-44-7.mol
(R)-4-Benzyl-2-oxazolidinone Structure
(R)-4-Benzyl-2-oxazolidinone Chemical Properties
Melting point 88-90 °C
alpha 62 º (C=1, CHCl3)
Boiling point 309.12°C (rough estimate)
density 1.1607 (rough estimate)
refractive index 14.5 ° (C=5, MeOH)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly)
pka12.78±0.40(Predicted)
form Crystalline Powder
color White to almost white
optical activity[α]18/D +64°, c = 1 in chloroform
Water Solubility Insoluble in water. Soluble in Chloroform.
Sensitive Hygroscopic
BRN 4782551
CAS DataBase Reference102029-44-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
F 3-10
HS Code 29349990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
(R)-4-Benzyl-2-oxazolidinone Usage And Synthesis
Description(R)-4-Benzyl-2-oxazolidinone is a derivative of oxazolidinone. It can be used in the preparation of enantiopure carbocyclic nucleosides, which act as a HIV protease inhibitor. It can also be used as a chiral auxiliary in the enantioselective synthesis of (2R, 2′S)-erythro-methylphenidate, beta-lactams and alpha-amino acids. Its end product includes asymmetric single isomeric drugs such as antitumor, anesthetic and entipasmodic products.
Chemical Propertieswhite to light yellow crystal powde
Usesintermediate for Aliskiren hemifumarate, Darifenacin HBr, Zolmitriptan
Uses(R)-(+)-4-Benzyl-2-oxazolidinones are used in the enantioselective synthesis of beta-lactams and alpha-amino acids. End products can include asysmmetric single isomeric drugs of antitumor, anesthetic, antipasmodic products. Used in the synthesis of HIV protease inhibitors. An oxazolidinone used in chiral auxiliary asymetric synthesis.
Referenceshttp://www.sigmaaldrich.com/catalog/product/aldrich/300977? lang=en®ion=US
https://www.alfa.com/en/catalog/A16770/ Shieh, Wen Chung, et al. "Synthesis of enantiomerically enriched 4- piperidinylglycine." US, US 6670477B2. 2003.
(R)-4-Benzyl-2-oxazolidinone Preparation Products And Raw materials
(3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE (R)-4-BENZYL-2-OXAZOLIDINONE LITHIUM SALT (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE (R)-(+)-4-BENZYL-5,5-DIMETHYL-2-OXAZOLIDINONE N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE,N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE (R)-4-BENZYL-3-(3-CYCLOPENTYL-PROPIONYL)-OXAZOLIDIN-2-ONE Z-D-Phenylalanine N-carboxyanhydride (R)-4-BENZYL-3-(3-CYCLOPROPYL-PROPIONYL)-OXAZOLIDIN-2-ONE (R)-4-BENZYL-3-(4-METHYL-PENTANOYL)-OXAZOLIDIN-2-ONE N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE,N-(ISOTHIOCYANOACETYL)-(4S)-BENZYL-2-OXAZOLIDINONE (R)-(+)-4-(DIPHENYLMETHYL)-2-OXAZOLIDIN& (R)-(+)-5,5-DIPHENYL-4-BENZYL-2-OXAZOLIDINONE (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one N-CROTONYL-(4R)-BENZYL 2-OXAZOLIDINONE (R)-4-Benzyl-2-oxazolidinone (R)-4-BENZYL-OXAZOLIDINE-2,5-DIONE (R)-4-(4-AMINOMETHYL-BENZYL)-OXAZOLIDIN-2-ONE N-(DIETHYLPHOSPHONOACETYL) (4R)-BENZYL-2-OXAZOLIDINONE
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