Thalidomide-O-PEG4-Propargyl

Thalidomide-O-PEG4-Propargyl Basic information
Product Name:Thalidomide-O-PEG4-Propargyl
Synonyms:Thalidomide-O-PEG4-Propargyl;4-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Thalidomide-PEG4-Propargyl;E3 Ligase Ligand-Linker Conjugates,Thalidomide-PEG-4-Propargyl,inhibit,Inhibitor,Thalidomide PEG4 Propargyl,ThalidomidePEG4Propargyl;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-
CAS:2098799-77-8
MF:C24H28N2O9
MW:488.49
EINECS:
Product Categories:peg
Mol File:2098799-77-8.mol
Thalidomide-O-PEG4-Propargyl Structure
Thalidomide-O-PEG4-Propargyl Chemical Properties
Boiling point 673.9±55.0 °C(Predicted)
density 1.320±0.06 g/cm3(Predicted)
solubility Soluble in Water, DMF, DCM, DMSO
pka10.70±0.40(Predicted)
Safety Information
HS Code 2933998090
MSDS Information
Thalidomide-O-PEG4-Propargyl Usage And Synthesis
DescriptionThalidomide-O-PEG4-Propargyl is synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst.
Thalidomide-O-PEG4-Propargyl Preparation Products And Raw materials
E3 Ligase Ligand-Linker Conjugates 20 Thalidomide-linker 13 tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-O-PEG4-Boc Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C4-NH2 hydrochloride Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-linker 10 E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 21 Cereblon Ligand 1 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-

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