AG 490

AG 490 Basic information
Product Name:AG 490
Synonyms:AG 490, Tryphostin B42;2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide;N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide;TYRPHOSTIN AG 490;TYROPHOSTIN AG490;TYRPHOSTIN B42;TYRPHOSTIN AG 490, 99+%;N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide
CAS:134036-52-5
MF:C17H14N2O3
MW:294.3
EINECS:604-604-1
Product Categories:Inhibitor;Aromatics;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors
Mol File:134036-52-5.mol
AG 490 Structure
AG 490 Chemical Properties
Melting point 215
Boiling point 615.2±55.0 °C(Predicted)
density 1.337±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility ethanol: 5 mg/mL
pka8.82±0.35(Predicted)
form solid
color yellow
CAS DataBase Reference134036-52-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-50-25
Safety Statements 26-36-61-45
WGK Germany 1
Hazard Note Irritant/Keep Cold under -20C
HS Code 2926907090
MSDS Information
ProviderLanguage
SigmaAldrich English
AG 490 Usage And Synthesis
Chemical PropertiesPale Yellow-Green Crystal
UsesA potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
UsesTyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.
DefinitionChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.
AG 490 Preparation Products And Raw materials
NS-398 Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) N-Benzylacrylamide AG 490 (Tyrphostin AG 490),AG 490,TYROPHOSTIN AG490,TYRPHOSTIN AG 490 AG 213 Tyrphostin AG 490 (N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) (A)

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