ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Other amino acid derivatives L-NIO DIHYDROCHLORIDE

L-NIO DIHYDROCHLORIDE

L-NIO DIHYDROCHLORIDE Basic information
Product Name:L-NIO DIHYDROCHLORIDE
Synonyms:N5-(1-IMINOETHYL)-L-ORNITHINE DIHYDROCHLORIDE;N(5)-(1-IMINOETHYL)-L-ORNITHINE HCL;N5-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE;L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORI DE POTENT IRREVERSIBLE N;L-N5-(1-Iminoethyl)Ornithine,HCl;L-NIO DIHYDROCHLORIDE;L-N5-(1-IMINOETHYL)-ORNITHINE 2HCL;L-N5-(1-IMINOETHYL)ORNITHINE, DIHYDROCHLORIDE
CAS:36889-13-1
MF:C7H15N3O2
MW:173.21
EINECS:
Product Categories:Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Nitric Oxide Reagents;Nitric Oxide
Mol File:36889-13-1.mol
L-NIO DIHYDROCHLORIDE Structure
L-NIO DIHYDROCHLORIDE Chemical Properties
Melting point 225-226°C
storage temp. -20°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
Safety Statements 24/25
HS Code 29224985
MSDS Information
ProviderLanguage
ACROS English
L-NIO DIHYDROCHLORIDE Usage And Synthesis
DescriptionL-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.
Chemical PropertiesWhite Crystalline Solid
UsesA potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
DefinitionChEBI: L-NIO is a L-alpha-amino acid.
Biological ActivityPotent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .
L-NIO DIHYDROCHLORIDE Preparation Products And Raw materials
L-Glutamine L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) L-Ornithine L-ORNITHINE DIHYDROCHLORIDE L(+)-Ornithine hydrochloride VINYL-L-NIO HYDROCHLORIDE L-NIO DIHYDROCHLORIDE ETHYL-L-NIO (HYDROCHLORIDE)
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