Pizotifen Malate

Pizotifen Malate Basic information
Product Name:Pizotifen Malate
Synonyms:sandomygranmalate;sanomtgran;4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID;PIZOTYLINE MALATE;PIZOTIFEN MALATE;9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate (1:1);malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1);Einecs 225-970-4
CAS:5189-11-7
MF:C23H27NO5S
MW:429.53
EINECS:225-970-4
Product Categories:Active Pharmaceutical Ingredients;Sandomigran, pizotyline
Mol File:5189-11-7.mol
Pizotifen Malate Structure
Pizotifen Malate Chemical Properties
Melting point 185-186° (dec)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Aqueous Acid (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
MSDS Information
Pizotifen Malate Usage And Synthesis
UsesAntimigraine
UsesPizotifen, C19H21NS· C4H6O5, is piperidine derivatives. Though antihistamines, it is mainly used because of their antiserotonergic properties.
UsesPizotifen Malate is an anti migraine drug.
DefinitionChEBI: A malate salt resulting from the reaction of equimolar amounts of pizotifen and malic acid. A sedating antihistamine with strong serotonin antagonist and weak antimuscarinic activity, it is used for the treatment of migraine and the prevention of headache ttacks during cluster periods.
Pizotifen Malate Preparation Products And Raw materials
N-[2-(acetyloxy)propyl]-N-[3-[4-(1,1-diMethylpropyl)phenyl]-2-Methylpropyl]-forMaMide Pizotifen 4-[3-[4-(1,1-diMethylpropyl)-phenyl]-2-Methylpropyl]-2,6-diMethylMorpholine 4-oxide Fenpropimorph (2R,6S)-rel-2,6-DiMethyl-4-(2-Methyl-3-phenylpropyl)Morpholine Hydrochloride EC 1.1.1.40 3-BENZYLTHIOPHENE 1-(2,6-Dichlorophenyl)-2-indolinone CYCLOHEPTANE Pizotifen Malate (METHOXYMETHYL)DIPHENYLPHOSPHINE OXIDE IBD 78

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