ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Methylpyridine 2-Picoline-N-oxide

2-Picoline-N-oxide

2-Picoline-N-oxide Basic information
Product Name:2-Picoline-N-oxide
Synonyms:2-PICOLINE-N-OXIDE 95%(MIN);2-Methylpyridine-N-oxide hemihydrate(2-Picoline-N-oxide hemihydrate);Alpha-picoline N-oxide, 2-Picoline N-oxide;2-Methyl-1-oxidopyridin-1-ium;a-Picoline 1-oxide;a-Picoline N-oxide;1-Oxylato-2-methylpyridinium;2-Picoline-N-oxide,98%
CAS:931-19-1
MF:C6H7NO
MW:109.13
EINECS:213-230-3
Product Categories:Pyridines;Pyridine;bc0001
Mol File:931-19-1.mol
2-Picoline-N-oxide Structure
2-Picoline-N-oxide Chemical Properties
Melting point 41-45 °C(lit.)
Boiling point 259-261 °C
density 1.1143 (rough estimate)
refractive index 1.5444 (estimate)
Fp >230 °F
form powder to lump to clear liquid
pkapK1:1.029(+1) (25°C)
color White or Colorless to Light yellow
Water Solubility soluble
Sensitive Hygroscopic
BRN 106916
CAS DataBase Reference931-19-1(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 2-methyl-, 1-oxide(931-19-1)
EPA Substance Registry System2-Methylpyridine-1-oxide (931-19-1)
Safety Information
Hazard Codes Xi,Xn,F
Risk Statements 36/37/38-20/21/22-10
Safety Statements 26-36-24/25-16
WGK Germany 3
F 3
TSCA Yes
HS Code 29333990
MSDS Information
ProviderLanguage
2-Picoline-N-oxide English
SigmaAldrich English
ACROS English
ALFA English
2-Picoline-N-oxide Usage And Synthesis
Chemical Propertieslight yellow to brown crystalline low melting mass
Uses2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates.
DefinitionChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides.
Application2-Methylpyridine 1-oxide is a useful building block for organic synthesis.
Purification MethodsPurify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.]
2-Picoline-N-oxide Preparation Products And Raw materials
Preparation Products4-(DIMETHYLAMINO)PYRIDINE-2-CARBOXYLIC ACID-->4-Nitropicolinaldehyde-->4-BROMOPYRIDINE-2-CARBALDEHYDE-->4-Bromo-2-pyridinemethanol-->4-Bromo-2-methylpyridine-->4-METHOXYPICOLINALDEHYDE
7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE-4-OXIDE 2-Chloro-5-chloromethylpyridine (Diethoxymethyl)diphenylphosphine oxide Iron oxide 2-Picoline 4-Methylpyridine NITRIC OXIDE 3-FLUORO-5-PICOLINE N-OXIDE Pyridine-N-oxide 2,2,6,6-Tetramethylpiperidinooxy 4-Chloro-3-picoline 1-Oxide Chromium picolinate Rutile NITROUS OXIDE 2-Picoline-N-oxide 4-NITRO-3-PICOLINE N-OXIDE,4-Nitro-3-picoline 1-oxide,4-Nitro-beta-picoline N-oxide,4-Nitro-3-picoline-N-oxide 99%,4-Nitro-B-picoline N-oxide 3-FLUORO-4-NITRO-5-PICOLINE N-OXIDE,3-FLUORO-4-NITRO-5-PICOLINE 1-OXIDE Iron oxide black
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