3-Chlorophenol

3-Chlorophenol Basic information
Product Name:3-Chlorophenol
Synonyms:3-chloro-1-hydroxybenzene;3-chloro-pheno;3-Hydroxychlorobenzene;m-chlorophenicacid;3-Chloro-1-benzenol;3-Cl-phenol;3-Chlorophenol,99%;3-Chlorophenol Standard
CAS:108-43-0
MF:C6H5ClO
MW:128.56
EINECS:203-582-6
Product Categories:Pyridines;Chlorine Compounds;Phenols;Alpha sort;C;CAlphabetic;Organics;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;CH;Pesticides&Metabolites;Organic Building Blocks;Oxygen Compounds
Mol File:108-43-0.mol
3-Chlorophenol Structure
3-Chlorophenol Chemical Properties
Melting point 31-34 °C (lit.)
Boiling point 214 °C (lit.)
density 1.218 g/mL at 25 °C (lit.)
vapor pressure 1 hPa (44 °C)
refractive index n20/D 1.563(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility Soluble in ethanol and ether.
pka8.85(at 25℃)
form Liquid After Melting
color Clear yellow to brownish
Odordistinct phenol-like odor
PH3.5 (27.7g/l, H2O, 20℃)
Water Solubility 27.7 g/L (20 ºC)
Merck 14,2154
BRN 1634401
Stability:Stable. Combustible. Incompatible with acid chlorides, oxidizing agents, acid anhydrides. Discolours in air.
CAS DataBase Reference108-43-0(CAS DataBase Reference)
NIST Chemistry ReferencePhenol, 3-chloro-(108-43-0)
EPA Substance Registry Systemm-Chlorophenol (108-43-0)
Safety Information
Hazard Codes Xn,N
Risk Statements 20/21/22-51/53
Safety Statements 28-61-28A
RIDADR UN 2020 6.1/PG 3
WGK Germany 2
RTECS SK2450000
9
Autoignition Temperature>600 °C
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29081000
Hazardous Substances Data108-43-0(Hazardous Substances Data)
ToxicityLD50 orally in rats: 0.57 g/kg (Deichmann)
MSDS Information
ProviderLanguage
3-Chlorophenol English
SigmaAldrich English
ACROS English
ALFA English
3-Chlorophenol Usage And Synthesis
Chemical PropertiesWhite to light yellow crystal.
Chemical PropertiesAll isomers have a characteristic odor.
Uses3-Chlorophenol is a halophenol with antifungal activity. 3-Chlorophenol is commonly used as a building block in the preparation of variety of biologically active compounds. Studies suggest that 3-Chlo rophenol can be used in the regeneration of vegetal activated carbons.
Uses3-Chlorophenol is widely used in the pharmaceutical, dyes and organic synthesis industry. It is an important intermediate in the synthesis of chemicals.
Uses3-Chlorophenol is generally used in building various polycyclic aromatic systems. It is also employed in palladium-catalyzed coupling reactions to synthesize aryl intermediates in synthetic organic chemistry.
DefinitionChEBI: 3-chlorophenol is a monochlorophenol carrying the chloro substituent at position 3.
General DescriptionWhite crystals with an odor of phenol. Sinks in and slowly dissolves in water.
Air & Water ReactionsDiscolors on exposure to air. Water soluble
Reactivity Profile3-Chlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents .
HazardToxic by skin absorption, inhalation, or ingestion.
Fire Hazard3-Chlorophenol is probably combustible.
Safety ProfilePoison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Flammable or combustible liquid. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS.
Potential ExposureMonochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.
ShippingUN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification MethodsIt could not be obtained solid by crystallisation from pet ether. It is best purified by distillation under reduced pressure. [Beilstein 6 IV 810.]
IncompatibilitiesMay form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.
Waste DisposalIncinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.
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