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| | Actarit Basic information |
| | Actarit Chemical Properties |
| Melting point | 173-175°C | | Boiling point | 449.1±28.0 °C(Predicted) | | density | 1.288±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO, Ethanol, Methanol | | form | Solid | | pka | 4.34±0.10(Predicted) | | color | White to Off-White | | Merck | 14,133 | | CAS DataBase Reference | 18699-02-0(CAS DataBase Reference) |
| Safety Statements | 24/25 | | RTECS | CY1542000 | | HS Code | 29163990 | | Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1.06, 1.30, 1.95, 2.03 i.p.; 5.68, 5.48, 5.48, 6.12 s.c.; 15.3, 14.7, 14.8, 15.4 orally (Toshida) |
| | Actarit Usage And Synthesis |
| Description | Actarit is an orally administered disease-modifying antirheumatic drug launched in
Japan. Although its structure resembles that of non-steroidal anti-inflammatory
drugs, it has no effect on experimental acute inflammation and has no analgesic or
antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are
mediated via modulation of production and serum level of interleukin-2 which
enhances production of suppressor T-cells to the immune system, thereby,
preventing development of articular lesions. | | Chemical Properties | Crystalline Solid | | Originator | Nippon Shlnyaku;Mltaublshl Kasel
(Japan) | | Uses | Antiarthritic | | Uses | Chronic rheumatoid arthritis | | Definition | ChEBI: Actarit is an anilide and a member of acetamides. | | Brand name | Orcl; Mover | | Purification Methods | Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.] |
| | Actarit Preparation Products And Raw materials |
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