FORMAMIDOXIME

FORMAMIDOXIME Basic information

Product Name:	FORMAMIDOXIME
Synonyms:	formamideoxime;formamidoxim;isuretin;n-hydroxy-methanimidamid;n-hydroxymethanimidamide;FORMAMIDOXIME;isouretin;Formamidoxim [German]
CAS:	624-82-8
MF:	CH4N2O
MW:	60.06
EINECS:	210-865-8
Product Categories:	pharmacetical;Imines/Amidines;Nitrogen Compounds;Organic Building Blocks
Mol File:	624-82-8.mol

FORMAMIDOXIME Chemical Properties

Melting point	112-115 °C(lit.)
Boiling point	95.06°C (rough estimate)
density	1.3000 (rough estimate)
refractive index	1.4840 (estimate)
storage temp.	2-8°C
pka	14.53±0.40(Predicted)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-40
Safety Statements	22-36
WGK Germany	3
RTECS	LQ4632000
HazardClass	IRRITANT
HS Code	2928009090

MSDS Information

Provider	Language
SigmaAldrich	English

FORMAMIDOXIME Usage And Synthesis

Uses	Formamidoxime may be used as inhibitor of DNA synthesis.
Biochem/physiol Actions	Formamidoxime undergoes oxidative cleavage of C==N bonds in tracheal smooth muscle cells catalyzed by liver cytochrome P450 producing NO. It inhibits replicative DNA synthesis. It has antitumor activity against L1210 leukemia.

FORMAMIDOXIME Preparation Products And Raw materials

Raw materials

Methanimidic acid, N-hydroxy-, ethyl ester-->ETHYL FORMIMIDATE HYDROCHLORIDE-->Diethyl ether-->POTASSIUM CYANIDE-->Water-->HYDROXYLAMINE-->Ethanol-->HYDROGEN CYANIDE

2-[5-(TRIFLUOROMETHYL)PYRID-2-YLTHIO]ACETAMIDE OXIME N'-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-N-(4,6-DIMETHOXYPYRIMIDIN-2-YL)IMINOFORMAMIDE N-(6-CHLOROPYRIDAZIN-3-YL)-N'-HYDROXYIMINOFORMAMIDE (ISOPROPYLSULFONYL)ACETAMIDE OXIME (4-(3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYLOXY))PHENYL)(HYDROXYIMINO)METHYLAMINE 3,5-BIS(TRIFLUOROMETHYL)BENZAMIDOXIME 3-(TRIFLUOROMETHYL)BENZAMIDOXIME 3-NITROBENZAMIDOXIME PHENOXYACETAMIDOXIME N-HYDROXY-PYRAZINE-2-CARBOXAMIDINE PTIO 4-(N,N-DIMETHYLSULFAMOYLOXY)BENZAMIDOXIME N'-HYDROXY-N-(5-METHYLISOXAZOL-3-YL)IMINOFORMAMIDE 2-[4-(1,3-DITHIOLAN-2-YL)PHENOXY]ACETAMIDOXIME N'-HYDROXY-4-([5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)BENZENECARBOXIMIDAMIDE FORMAMIDOXIME BENZAMIDOXIME HYDROCHLORIDE Pyrazinecarboximidamide,3-chloro-N-hydroxy-

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