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| | D-PANTOTHENIC ACID Basic information |
| | D-PANTOTHENIC ACID Chemical Properties |
| Melting point | 178-179℃ | | alpha | D25 +37.5° | | Boiling point | 360.05°C (rough estimate) | | density | 1.266 | | refractive index | 1.4315 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Oil to Gel | | pka | 4.30±0.10(Predicted) | | color | Colourless | | Stability: | Hygroscopic | | LogP | -0.856 (est) | | EPA Substance Registry System | D-Pantothenic acid (79-83-4) |
| | D-PANTOTHENIC ACID Usage And Synthesis |
| Physical properties | Pantothenic acid is composed of β-alanine joined to 2,4-dihydroxy-3,3-
dimethylbutyric acid via an amide linkage. The molecule has an asymmetric center,
and only the R-enantiomer, usually called D-(+)pantothenic acid, is biologically
active and occurs naturally. Appearance: pantothenic acid is a yellow, viscous oil.
Its calcium and other salts, however, are colorless crystalline substances; calcium
pantothenate is the main product of commerce. Solubility: neither form is soluble in
organic solvents, but each is soluble in water and ethanol. Stability: aqueous solu tions of pantothenic acid are unstable when heated under acidic or alkaline
conditions | | Originator | Panto-250 , Bio-Tech Pharmacal | | Uses | Pantothenic Acid is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources. | | Uses | Vitamin B5 is water-soluble. It is required for proper growth and maintenance of the body and is involved in body processes such as energy release from carbohydrates and metabolism of fatty acids. It is relatively stable through storage and is found in liver, eggs, and meat. | | Uses | Labelled Pantothenic Acid | | Definition | ChEBI: (R)-pantothenic acid is a pantothenic acid having R-configuration. It has a role as an antidote to curare poisoning, a human blood serum metabolite and a geroprotector. It is a vitamin B5 and a pantothenic acid. It is a conjugate acid of a (R)-pantothenate. | | Manufacturing Process | Isobutylaldehyde reacted with formaldehyde in the presence potassium chromate as a result 2,2-dimethyl-3-hydroxy-propanal was obtained.
The 2,2-dimethyl-3-hydroxy-propanal was treated by sodium cyanide so 2,4dihydroxy-3,3-dimethyl-butironitrile was prepared.
The 2,4-dihydroxy-3,3-dimethyl-butironitrile was treated hydrochloric acid and D,L-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one (D,L-pantolacton) was obtained. The racemic mixture of D- and L-pantolactons was a division of Dand L- isomers by the adding of α-phenylethylamine. So D-pantolacton was isolated.
Acrylic acid contacted with NH3and β-alanine was obtained.
D-Pantalacton reacted with β-alanine as a result 3-(2,4-dihydroxy-3,3dimethyl-butyrylamino)-propanoic acid was produced | | Brand name | Calpan (BASF); Pantholin
(Lilly). | | Therapeutic Function | Vitamin | | Safety Profile | Moderately toxic by subcutaneous and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx. |
| | D-PANTOTHENIC ACID Preparation Products And Raw materials |
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