ORIENTIN

ORIENTIN Basic information

Product Name:	ORIENTIN
Synonyms:	2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one;ORIDONIN (RG);4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-.beta.-D-glucopyranosyl-5,7-dihydroxy-;Aids026706;Aids-026706;8-Glucosylluteolin;ORIENTIN;ORIENTINE
CAS:	28608-75-5
MF:	C21H20O11
MW:	448.38
EINECS:
Product Categories:	chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Aromatics, Glucuronides, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:	28608-75-5.mol

ORIENTIN Chemical Properties

Melting point	260-285°C
Boiling point	816.1±65.0 °C(Predicted)
density	1.759±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	1 M NaOH: soluble1mg/mL, clear, yellow-orange
pka	6.24±0.40(Predicted)
form	powder
color	yellow
Stability:	Hygroscopic
LogP	1.580 (est)

Safety Information

Safety Statements	24/25
WGK Germany	3
RTECS	DJ3009300
HS Code	29389090

MSDS Information

ORIENTIN Usage And Synthesis

Description	Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC₅₀ value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC₅₀ value of 11.7 μg/ml and a cytotoxic concentration (CC₅₀) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.
Chemical Properties	Yellow powder
Uses	Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.
Definition	ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.

ORIENTIN Preparation Products And Raw materials

(S)-4-BENZYLOXY-1,2-BUTANEDIOL 1-PHENYL-2-BUTANOL 4-N-HEXYLPHENOL (S)-(+)-1-Phenyl-1,2-ethanediol NSC46644 (S)-(-)-3-BENZYLOXY-1,2-PROPANEDIOL 1-(3-METHYLPHENYL)ETHANOL 2,4-DIETHYL-1,3-BENZENEDIOL TRICETIN-6,8-DI-C-GLUCOSIDE 4'-Hydroxy-3'-methylacetophenone 1-(2-Hydroxy-5-methylphenyl)ethanone ORIENTIN 5-ETHYL-2-HYDROXY-BENZALDEHYDE 5'-ETHYL-2'-HYDROXYACETOPHENONE (R)-1-PHENYL-1,3-PROPANEDIOL 1-(2,4-DIHYDROXY-5-PROPYLPHENYL)ETHAN-1-ONE (S)-(+)-4-PHENYL-2-BUTANOL 3-(2-METHOXY-PHENYL)-PROPAN-1-OL

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