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| | Diazinon Basic information |
| | Diazinon Chemical Properties |
| Melting point | >120°C (dec.) | | Boiling point | 306°C | | density | 1.117 | | vapor pressure | 1.2 x 10-2 Pa (25 °C) | | refractive index | nD20 1.4978-1.4981 | | Fp | 104.4 °C | | storage temp. | APPROX 4°C
| | solubility | Chloroform: Slightly Soluble | | pka | 1.21±0.30(Predicted) | | form | neat | | Water Solubility | Slightly soluble. 0.004 g/100 mL | | Merck | 13,3019 | | BRN | 273790 | | Exposure limits | OSHA PEL: TWA 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3. | | Stability: | Moisture Sensitive | | CAS DataBase Reference | 333-41-5(CAS DataBase Reference) | | IARC | 2A (Vol. 112) 2017 | | NIST Chemistry Reference | Diazinone(333-41-5) | | EPA Substance Registry System | Diazinon (333-41-5) |
| | Diazinon Usage And Synthesis |
| Description | Diazinon is a non-systemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon functions as the inhibitor of acetylcholinesterase (AChE), which breaks down the neurotransmitter acetylcholine (ACh) into [choline] and an acetate group. The inhibition of the AChE causes an abnormal accumulation of ACh in the synaptic cleft. However, recent studies have shown that diazinon and other kinds of organophosphate can cause neural toxicity through causing oxidative stress in the neural cells.
| | Description | Diazinon is a broad-spectrum insecticide that is active against approximately 120 species of insects and pests. It is metabolized into the cholinesterase inhibitors monothionotetraethyl pyrophosphate, dithionotetraethyl pyrophosphate, and triethylthionophosphate in vivo, which induce vomiting, fasciculation with muscular twitching, paralysis, and death (LD50 = 125 mg/kg) in rats. Diazinon induces formation of capsular adhesion in the kidneys and ulcer formation in the duodenum of dogs as well as mucosal erosion and serosal seepage in the intestines of mini pigs. Formulations containing diazinon were previously used as agricultural pesticides. | | Chemical Properties | Diazinon is available as a colorless or dark brown liquid. It is sparingly soluble in water
but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control
of a variety of agricultural and household pests. These include pests in soil, on ornamental
plants, fruit, vegetable, crops pests, and household pests like fl ies, fl eas, and cockroaches.
Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes, such
as nitrogen oxides, phosphorous oxides, and sulfur oxides. It reacts with strong acids and
alkalis with the possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon
is classifi ed as an RUP. Depending on the type of formulation, diazinon is classifi ed as
toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic. | | Chemical Properties | Diazinon is a combustible, colorless, oily
liquid. Faint amine odor. Technical grade is pale to dark brown. Commercial formulations may use carrier solvents
which can change the physical properties listed here. | | Uses | insecticide, cholinesterase inhibitor | | Uses | A cholinesterase inhibitor; a nonsystemic organophosphate insecticide. | | Uses | Nonsystemic contact insecticide used against flies, aphids and spider mites in soil,
fruit, vegetables and ornamentals. | | Uses | Diazinon is used to control a wide range of sucking and chewing
insects and mites in a very wide range of crops and is also used as a
veterinary ectoparasiticide. | | Definition | ChEBI: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4. | | General Description | Diazinon is available in the form of a colourless or dark brown liquid. It is sparingly soluble in water but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control of a variety of agriculture and household pests. These include pests in soil, on ornamental plants, fruit, vegetable, and crops and household pests like flies, fleas, and cockroaches. Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes such as nitrogen oxides, phosphorus oxides, and sulphur oxides. It reacts with strong acids and alkalis with possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon is classified as a RUP. Depending on the type of formulation, diazinon is classified as toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic.
| | Air & Water Reactions | The neat compound is susceptible to oxidation and should be protected from prolonged exposure to air . Insoluble in water. | | Health Hazard | LIQUID: POISONOUS IF SWALLOWED. Irritating to skin and eyes. | | Health Hazard | Humans are exposed to diazinon during manufacture and professional applications. Diazinon
causes poisoning with symptoms such as headache, dizziness, nausea, weakness, feelings of
anxiety, vomiting, pupillary constriction, convulsions, respiratory distress or labored breathing,
unconsciousness, muscle cramp, excessive salivation, respiratory failure, and coma. | | Health Hazard | Cholinesterase inhibitor; moderately toxic byingestion and skin absorption; ingestion ofapproximately large quantities of 10–15 gcan produce cholinergic effects in adulthuman; poisoning symptoms include headache, dizziness, weakness, blurred vision,pinpoint pupils, salivation, muscle spasms,vomiting abdominal pain, and respiratorydepression; LD50 values in experimentalanimals show wide variation.
LD50 oral (rat): within the range 100–300mg/kg
LD50 oral (guinea pig): 250 mg/kg. | | Fire Hazard | Not flammable. POISONOUS GASES ARE PRODUCED WHEN HEATED. Oxides of sulfur and of phosphorus are generated in fires. | | Agricultural Uses | Insecticide, Acaricide: Diazinon is the most widely used pesticide by
homeowners on lawns, and is one of the most widely used
pesticide ingredients for application around the home and
in gardens. It is used to control insects and grub worms.
It is a nonsystemic organophosphate insecticide used to
control cockroaches, silverfish, ants, and fleas in residential,
non-food buildings. Bait is used to control scavenger
yellow jackets in the western U.S. It is used on home
gardens and farms to control a wide variety of sucking
and leaf-eating insects. It is used on rice, fruit trees,
sugarcane, corn, tobacco, potatoes and on horticultural
plants, and is also an ingredient in pest strips. Diazinon
has veterinary uses against fleas and ticks. It is available
in dust, granules, seed dressings, wettable powder, and
emulsifiable solution formulations. In 1988, there were
500 different products containing diazinon on the market,
and used in such products as agricultural sprays and
granules, animal ear tags, household sprays and dust and
veterinary products. Not approved for use in EU countries.
A U.S. EPA restricted Use Pesticide (RUP). The
U.S. EPA initiated a program to phase out all non-agricultural
uses of diazinon commencing in March, 2001. Many
commercial outdoor uses of diazinon have been canceled
or restricted to licensed pesticide applicators because of
its known toxicity to birds and aquatic life. Diazinon is
highly toxic to bees and very highly toxic to birds, fish
and aquatic invertebrates. Diazinon was canceled for use
on golf courses and sod farms in 1988 because of its high
risk to birds | | Trade name | AG-500®; AI3-19507®; ALFA-TOX®[C];
ANTIGAL®; ANTLAK®; BASUDIN®; BAZUDEN®;
CASWELL No. 342®; DACUTOX®; DASSITOX®;
DAZZEL®; DIAGRAN®; DIANON®; DIATERR-FOS®;
DIAZAJET®; DIAZATOL®; DIAZIDE®; DIAZINON AG
500 WBC®; DIAZINONE®; DIAZITOL®; DIAZOL®;
DICID®; DIMPYLATE®; DIPOFENE®; DIZIKTOL®;
DIZINON®[C]; DRAWIZON®; DYMET®; DYZOL®);
D.Z.N.®; EXODIN®; FEZUDIN®; FLYTROL®; G 301®;
G-24480®; GALESAN®; GARDENTOX®; GEIGY
24480®; KAYAZINON®; KAYAZOL®; NEOCIDOL®
(OIL); NEOCIDOL®; NIPSAN®; NUCIDOL®;
OLEODIAZINON®; ROOT GUARD; SAROLEX®[C];
SPECTRACIDE®; SROLEX®; SUZON® | | Safety Profile | Poison by ingestion,
skin contact, subcutaneous, intravenous, and intraperitoneal routes. Mildly toxic by
inhalation. Human systemic effects by
ingestion: changes in motor activity, muscle
weakness, and sweating. Experimental
teratogenic and reproductive effects. A skin
and severe eye irritant. Human mutation
data reported. When heated to
decomposition it emits very toxic fumes of
NOx, POx, and SOx. | | Potential Exposure | roducers, formulators and applicators
of this nonsystemic pesticide and acaricide. Diazinon is
used in the United States on a wide variety of agricultural
crops, ornamentals, domestic animals; lawns and gardens;
and household pests. | | Carcinogenicity | Among 23,106 male applicators
participating in the Agricultural Health Study who
reported using diazinon, there was an increased risk with
exposure to diazinon for lung cancer, leukemia, and all
cancer sites combined, although the small number of cases
observed makes these estimates unreliable . | | Environmental Fate | Biological. Sethunathan and Yoshida (1973a) isolated a Flavobacterium sp. (ATCC 27551) from rice paddy water that metabolized diazinon as the sole carbon source. Diazinon was readily hydrolyzed to 2-isopropyl-4-methyl-6-hydroxypyrimidine under aerobic conditions but less rapidly under anaerobic conditions. This bacterium as well as enrichment cultures isolated from a diazinon-treated rice field mineralized the hydrolysis product to carbon dioxide (Sethunathan and Pathak, 1971; Sethunathan and Yoshida, 1973). Rosenberg and Alexander (1979) demonstrated that two strains of Pseudomonas grew on diazinon and produced diethyl phosphorothioate as the major end product. The rate of microbial degradation increased in the presence of an enzyme (parathion hydrolase), produced by a mixed culture of Pseudomonas sp. (Honeycutt et al., 1984).
Soil. Hydrolyzes in soil to 2-isopropyl-4-methyl-2-hydroxypyrimidine, diethylphosphorothioic acid, carbon dioxide (Getzin, 1967; Lichtenstein et al., 1968; Sethunathan and Yoshida, 1969; Sethunathan and Pathak, 1972; Bartsch, 1974; Wolfe et al., 1976; Somasundaram and Coats, 1991) and tetraethylpyrophosphate (Paris and Lewis, 1973). The half-life of diazinon in soil was observed to be inversely proportional to temperature and soil moisture content (Getzin, 1968). Seven months after diazinon was applied on a sandy loam (2 kg/ha), only 1% of the total applied amount remained and 10% was detected in a peat loam (Suett, 1971).
The reported half-life in soil is 32 days (Jury et al., 1987). Reported half-lives in soil following incubation of 10 ppm diazinon in sterile sand loam, sterile organic soil, nonsterile sandy loam and nonsterile organic soil are 12.5, 6.5, <1 and 2 weeks, respectively (Miles et al., 1979). The reported half-life of diazinon in sterile soil at pH 4.7 was 43.8 days (Sethunathan and MacRae, 1969). Major metabolites identified were diethyl thiophosphoric acid, 2-isopropyl-4-methyl-6-hydroxypyrimidine and carbon dioxide (Konrad et al., 1967). When soil is sterilized, the persistence of diazinon increased more so than changes in soil moisture, soil type or rate of application (Bro-Rasmussen et al., 1968). The halflives for diazinon in flooded soil incubated in the laboratory ranged from 4 to 17 days with an average half-life of 10 days (Sethunathan and MacRae, 1969; Sethunathan and Yoshida, 1969; Laanio et al., 1972). The mineralization half-life for diazinon in soil was 5.1 years (Sethunathan and MacRae, 1969; Sethunathan and Yoshida, 1969).
The half-lives of diazinon in a sandy loam, clay loam and an organic amended soil under nonsterile conditions were 66–1,496, 49–1,121 and 14–194 days, respectively, while under sterile conditions the half-lives were 57–1,634, 46–1,550 and 14–226 days, respectively (Schoen and Winterlin, 1987).
In a silt loam and sandy loam, reported Rf values were 0.86 and 0.88, respectively (Sharma et al., 1986).
Surface Water. In estuarine water, the half-life of diazinon ranged from 8.2 to 10.2 days (Lacorte et al., 1995).
Groundwater. According to the U.S. EPA (1986) diazinon has a high potential to leach to groundwater.
Plant. Diazinon was rapidly absorbed by and translocated in rice plants. Metabolites identified in both rice plants and a paddy soil were 2-isopropyl-4-methyl-6-hydroxypyrimidine (hydrolysis product), 2-(1¢-hydroxy-1¢-methyl)ethyl-4-methyl-6-hydroxypyrimidine and other polar compounds (Laanio et al., 1972). Oxidizes in plants to diazoxon (Ralls et al., 1966; Laanio et al., 1972; Wolfe et al., 1976) although 2-isopropyl-4-methyl- 6-pyrimidin-6-ol was identified in bean plants (Kansouh and Hopkins, 1968) and as a hydrolysis product in soil (Somasundaram et al., 1991) and water (Suffet et al., 1967). Five days after spraying, pyrimidine ring-labeled 14C-diazinon was oxidized to oxodiazinon which was then hydrolyzed to 2-isopropyl-4-methylpyrimidin-6-ol which in turn, was further metabolized to carbon dioxide (Ralls et al., 1966). Diazinon was transformed in field-sprayed kale plants to form hydroxydiazinon {O,O-diethyl-O-[2-(2¢-hydroxy-2¢-propyl)- 4-methyl-6-pyrimidinyl] phosphorothioate} which was not previously reported (Pardue et al., 1970). | | Metabolic pathway | The main route of diazinon metabolism in soil, plants and animals is
through cleavage of the P-O-pyrimidine group to yield 2-isopropyl-4-
methyl-6-hydroxypyrimidine. As with most other phosphorothioates,
loss of the pyrimidinyl function in mammalian metabolism probably
occurs either through oxidative desulfuration of the thiono group, catalysed
by microsomal mixed function oxidases, to give diazoxon followed
by hydrolysis catalysed by an A-esterase, or via an oxidative mechanism
catalysed by a mixed function oxidase acting directly on diazinon. In the
first case the second product is diethyl phosphate and in the second,
diethyl phosphorothioate (Yang et al., 1971). Further metabolism then
leads to hydroxylation of the methyl and isopropyl groups on the pyrimidine
ring. This oxidative metabolism may the act on the pyrimidinol,
diazoxon or diazinon itself, the last of which seems to be important in
mammalian and avian liver and gives rise to metabolites which still have
anticholinesterase or latent anticholinesterase activity. | | Metabolism | The main biodegradation pathway in mammals, plants,
and soils is pyrimidinyl ester bond cleavage; the principal
metabolites are diethyl phosphorothioate and diethyl
phosphate. Degradation in the environment involves
oxidation to diazoxon and hydrolysis. | | Shipping | UN2783 Organophosphorus pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | | Toxicity evaluation | The acute oral LD50 for rats and mice are 1250
and 80–135 mg/kg. Inhalation LC50 (4 h) for rats is
>2330 mg/m3 air. NOEL (2 yr) for rats is 0.06 mg/kg/d. | | Degradation | Diazinon(1) is stable at neutral pH but is slowly hydrolysed in alkaline
solutions and rapidly at acidic pH values (PM). Hydrolysis products
were identified as the pyrimidinol (2) and diethyl phosphorothioate (3)
(PSD, 1991).
When diazinon was dissolved in a water/soil suspension and irradiated
with UV light, Mansour et al. (1997) demonstrated that one of the
products was iso-diazinon (4) formed via a thiono-thiolo rearrangement
(see Scheme 1). | | Incompatibilities | Reaction with nitrosating agents (e.g.,
nitrites, nitrous gases, nitrous acid) capable of releasing carci-
nogenic nitrosamines. Hydrolyzes slowly in water and dilute
acid. Reacts with strong acids and alkalis with possible forma-
tion of highly toxic tetraethyl thiopyrophosphates.
Incompatible with copper-containing compounds. Contact
with oxidizers may cause the release of phosphorous oxides.
Contact with strong reducing agents, such as hydrides; may
cause the formation of flammable and toxic phosphine gas. | | Waste Disposal | Diazinon is hydrolyzed in
acid media about 12 times as rapidly as parathion, and
at about the same rate as parathion in alkaline media. In
excess water this compound yields diethylthiophosphoric
acid and 2-isopropyl-4-methyl-6-hydroxypyrimidine. With
insufficient water, highly toxic tetraethyl monothiopyropho-
sphate is formed. Therefore, incineration would be a prefer-
able ultimate disposal method with caustic scrubbing of
the incinerator effluent
. In accordance with 40CFR165,
follow recommendations for the disposal of pesticides and
pesticide containers. Must be disposed properly by follow-
ing package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office. | | Precautions | Workers should avoid eye contact with diazinon, wear chemical safety glasses or goggles,
protective clothing or equipment, wear waterproof boots, long-sleeved shirts, long pants,
and a hat. Workers should avoid contamination of food and feed, wash thoroughly after
handling and before eating or smoking. In fact, occupational workers should avoid eating,
drinking, or smoking in areas of work with the chemical. | | References | Uner, N, et al. "Effects of diazinon on acetylcholinesterase activity and lipid peroxidation in the brain of Oreochromis niloticus." Environmental Toxicology & Pharmacology 21.3(2006):241.
Shishido, Takashi, K. Usui, and J. I. Fukami. "Oxidative metabolism of diazinon by microsomes from rat liver and cockroach fat body." Pesticide Biochemistry & Physiology 2.1(1972):27-38.
Giordano, G, et al. "Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency." Toxicology & Applied Pharmacology 219.2-3(2007):181.
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| | Diazinon Preparation Products And Raw materials |
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