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| | Glabridin Basic information |
| Product Name: | Glabridin | | Synonyms: | 1,3-Benzenediol, 4-(3,4-dihydro-8,8-diMethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-;(R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol;4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol;Glabridin, >=98%;Glabridin/Propylene Glycol;4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol;Glabridin/OIL SOLUBLE LICORICE(GLYCYRRHIZA) EXTRACT;professional manufacturer Glabridin 59870-68-7 | | CAS: | 59870-68-7 | | MF: | C20H20O4 | | MW: | 324.37 | | EINECS: | 611-908-7 | | Product Categories: | Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Natural Plant Extract;59870-68-7 | | Mol File: | 59870-68-7.mol |  |
| | Glabridin Chemical Properties |
| Melting point | 154～155℃ | | Boiling point | 518.6±50.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | Fp | 267℃ | | storage temp. | room temp | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | pka | 9.66±0.40(Predicted) | | form | powder | | color | white to light brown | | BRN | 7141956 | | Stability: | Hygroscopic | | InChI | InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 | | InChIKey | PMPYOYXFIHXBJI-ZDUSSCGKSA-N | | SMILES | C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1 | | LogP | 4.260 (est) | | CAS DataBase Reference | 59870-68-7(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29329990 |
| | Glabridin Usage And Synthesis |
| Chemical Properties | White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc. | | Uses | Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative. | | Definition | ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan. | | benefits | Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant. | | Biochem/physiol Actions | Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to posses varies biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9. | | References | Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel ?uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013); |
| | Glabridin Preparation Products And Raw materials |
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