ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Ethyl compound 3-Amino-2-butenoic acid ethyl ester

3-Amino-2-butenoic acid ethyl ester

3-Amino-2-butenoic acid ethyl ester Basic information
Product Name:3-Amino-2-butenoic acid ethyl ester
Synonyms:Ethyl (2E)-3-amino-2-butenoate;ETHYL 3-AMINO-2-BUTENOATE;ETHYL 3-AMINOCROTONATE;ETHYL (2E)-3-AMINOBUT-2-ENOATE;ETHYL BETA-AMINOCROTONATE;ETHYL B-IMINOBUTYRATE;β-Aminocrotonic acid, ethyl ester;Ethyl 3-aminocrotonate, 98.50%
CAS:7318-00-5
MF:C6H11NO2
MW:129.16
EINECS:230-782-0
Product Categories:API intermediates
Mol File:7318-00-5.mol
3-Amino-2-butenoic acid ethyl ester Structure
3-Amino-2-butenoic acid ethyl ester Chemical Properties
Melting point 33-35 °C(lit.)
Boiling point 210-215 °C(lit.)
density 1.022 g/mL at 25 °C(lit.)
refractive index 1.5-1.502
Fp 207 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Chloroform, Methanol
pka5.32±0.70(Predicted)
form Low Melting Solid or Liquid
color Slightly yellow
CAS DataBase Reference7318-00-5(CAS DataBase Reference)
NIST Chemistry Reference2-Butenoic acid, 3-amino-, ethyl ester(7318-00-5)
Safety Information
Hazard Codes C
Risk Statements 34-36/37
Safety Statements 26-27-28-36/37/39-45-24/25
RIDADR UN 3263 8/PG 2
WGK Germany 3
HS Code 29224999
MSDS Information
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3-Amino-2-butenoic acid ethyl ester Usage And Synthesis
Chemical PropertiesSlightly yellow low melting solid or liquid
UsesEthyl 3-Aminocrotonate is used as a reagent to synthesize Nitrendipine (N490150), a calcium channel antagonist that is used to treat patients with hypertension. Ethyl 3-Aminocrotonate is also used as a reagent to synthesize (S)-Felodipine (F232370), a calcium entry blocker that has antihypertensive properties.
3-Amino-2-butenoic acid ethyl ester Preparation Products And Raw materials
Preparation Products2,5-Dimethylpyridine-->Felodipine
Nicardipine hydrochloride ETHYL 7-METHYL-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE ETHYL 7-METHYL-2-(2-THIENYL)PYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE Ethyl 3-(methylamino)-2-butenoate ETHYL 3-(4-CHLOROANILINO)CROTONATE ETHYL 2-AZEPAN-2-YLIDENACETATE 1,4-BUTANEDIOL BIS(BETA-AMINOCROTONATE) ETHYL 2,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLATE Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate ETHYL 2-(4-CHLOROPHENYL)-7-METHYLPYRAZOLO[1,5A]PYRIMIDINE-6-CARBOXYLATE 2,2-DIMETHYL-5-(2-TETRAHYDROPYRROLYLIDENE)-1,3-DIOXANE-4,6-DIONE 2,2-DIMETHYL-5-(2-HEXAHYDROAZEPINYLIDENE)-1,3-DIOXAN-4,6-DIONE Ethyl 3-anilinobut-2-enoate 2,2-Dimethyl-5-(2-piperidinylidene)-1,3-dioxane-4,6-dione DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 3-Amino-2-butenoic acid ethyl ester 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
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