ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Methylpyridine 2-Chloro-4-picoline

2-Chloro-4-picoline

2-Chloro-4-picoline Basic information
Product Name:2-Chloro-4-picoline
Synonyms:4-Picoline, 2-chloro-;Pyridine, 2-chloro-4-methyl-;2-CHLORO-GAMMA-PICOLINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE;2-chloro-4-methylpyrdine;2-CHLORO-4-PICOLINE 2-CHLORO-4-METHYLPYRIDINE;2-CHLORO-4-METHYLPYRIDINE (2-CHLORO-4-PICOLINE)
CAS:3678-62-4
MF:C6H6ClN
MW:127.57
EINECS:222-951-2
Product Categories:Pyridine;pyridine derivative;pyridine series;Chloropyridines;Halopyridines;Halides;Pyridines
Mol File:3678-62-4.mol
2-Chloro-4-picoline Structure
2-Chloro-4-picoline Chemical Properties
Melting point 115°C
Boiling point 194-195 °C (lit.)
density 1.142 g/mL at 25 °C (lit.)
refractive index n20/D 1.529(lit.)
Fp 193 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid
pka0.94±0.10(Predicted)
Specific Gravity1.14
color Clear colorless to light yellow
CAS DataBase Reference3678-62-4(CAS DataBase Reference)
NIST Chemistry Reference2-Cl-4-(CH3)-pyridine(3678-62-4)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36-36/37/39
WGK Germany 3
HazardClass IRRITANT, IRRITANT-HARMFUL
HS Code 29349990
MSDS Information
ProviderLanguage
2-Chloro-4-methylpyridine English
SigmaAldrich English
ACROS English
2-Chloro-4-picoline Usage And Synthesis
Chemical PropertiesColorless to light yellow liquid.
Uses2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.
General Description2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.
2-Chloro-4-picoline Preparation Products And Raw materials
Preparation Products2-CYANO-4-METHYLPYRIDINE
3-Chloro-2-formyl-4-methylpyridine 4-Bromo-2-chloro-3-picoline 2-CHLORO-4,6-DIMETHYL-5-NITRO-NICOTINONITRILE 3-BROMO-2-CHLORO-6-PICOLINE (3-BROMO-2-CHLORO-6-METHYLPYRIDINE) 2-AMINO-3-CHLORO-5-PICOLINE,6-AMINO-5-CHLORO-3-PICOLINE 2,6-DICHLORO-4-METHYLNICOTINAMIDE 2-(Chloromethyl)pyridine 5-BROMO-2-CHLORO-3-PICOLINE ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 3-Bromo-5-Chloro-2-Picoline 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 2-Acetamido-5-Chloro-6-Picoline 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE 5-CHLORO-3-PICOLINE 2-AMINO-3-HYDROXY-5-CHLORO-4-PICOLINE 5-Chloro-4-methylpyridine-2,3-diamine 2,6-Dichloro-4-methylnicotinonitrile 2-CHLOROLEPIDINE
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