|
| | Phenyl chlorothionocarbonate Basic information |
| | Phenyl chlorothionocarbonate Chemical Properties |
| Melting point | 51 °C | | Boiling point | 81-83 °C/6 mmHg (lit.) | | density | 1.248 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.581(lit.) | | Fp | 179 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform, Ethyl Acetate | | form | Liquid | | Specific Gravity | 1.248 | | color | Clear yellow | | Water Solubility | decomposes | | Sensitive | Moisture Sensitive | | BRN | 774830 | | CAS DataBase Reference | 1005-56-7(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29309070 |
| | Phenyl chlorothionocarbonate Usage And Synthesis |
| Chemical Properties | CLEAR YELLOW LIQUID | | Uses | O-Phenyl chlorothionoformate has been used in:
- stereodirected synthesis of optically active, (?)-mintlactone
- synthesis of peptide α-thioesters having a variety of C-terminal amino acids
- synthesis of scyllo-inositol derivatives
- thionocarbonylation of unprotected thymine nucleosides
- preparation of phenoxythiocarbonyl esters of protected ribonucleosides
| | Uses | Phenyl Chlorothionoformate is used in the preparation of an bicyclic thymidine analogs as selective inhibitors of Thymidine monophosphate kinase Mycobacterium tuberculosis (TMPKmt).
| | Purification Methods | Purify it by dissolving in CHCl3, washing with H2O, drying (CaCl2), filtering, evaporating and distilling twice under a vacuum to give a clear yellow liquid. It is reactive and POISONOUS—work in a fume cupboard. Store it in sealed ampoules under N2. A possible impurity is O,O'-diphenyl thiocarbonate which has m 106o and remains behind in the distilling flask. [B.gemann et al. in Methoden Der Organischen Chemie (Houben-Weyl) 4th edn (E. Müller Ed.) Vol 9 Schwefel-Selen-Tellur Verbindungen pp. 807-808 1955, Rivier & Schalch Helv Chim Acta 6 612 1923, Kalson Chem Ber 20, 2384 1987, Rivier & Richard Helv Chim Acta 8 490 1925, Sch.nberg & Varga Justus Liebigs Ann Chem 483 176 1930, Sch.nberg & Vargha Chem Ber 64 1390 1931, Beilstein 6 III 609.] |
| | Phenyl chlorothionocarbonate Preparation Products And Raw materials |
|
