S-Carboxymethyl-L-Cysteine

S-Carboxymethyl-L-Cysteine Basic information
Product Name:S-Carboxymethyl-L-Cysteine
Synonyms:(l)-2-amino-3-(carboxymethylthio)propionicacid;(r)-s-(carboxymethyl)cysteine;carbocisteine;l.j.206;l-3-((carboxymethyl)thio)alanine;l-carboxymethylcysteine;3-[(CARBOXYMETHYL)THIO]ALANINE;3-CARBOXYMETHYLTHIO-L-ALANINE
CAS:638-23-3
MF:C5H9NO4S
MW:179.19
EINECS:211-327-5
Product Categories:Pyrans;API intermediates;Food and Feed Additive;Small molecule;Mainly used in chronic bronchitis, bronchial asthma and other diseases caused by sticky sputum, cough phlegm difficulties and phlegm obstruction airway disease treatment;API;PROTECTED AMINO ACID & PEPTIDES;Amino Acids;Cysteine [Cys, C];Nutritional Supplements;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Amino Acid Derivatives;Cysteine/Cystine;Peptide Synthesis;A - H;Amino Acids;Modified Amino Acids
Mol File:638-23-3.mol
S-Carboxymethyl-L-Cysteine Structure
S-Carboxymethyl-L-Cysteine Chemical Properties
Melting point 208-213 °C (dec.)
alpha -31 º (c=1, 10% NaH2CO3)
Boiling point 417.3±45.0 °C(Predicted)
density 1.315 (estimate)
refractive index 1.5216 (estimate)
storage temp. 2-8°C
solubility Aqueous Acid, Aqueous Base (Sparingly, Sonicated)
pka2.06±0.10(Predicted)
form Amorphous Powder
color White to slightly off-white
Water Solubility SOLUBLE IN COLD WATER
Merck 14,1802
BRN 1725012
LogP0.204 (est)
CAS DataBase Reference638-23-3(CAS DataBase Reference)
EPA Substance Registry SystemL-Cysteine, S-(carboxymethyl)- (638-23-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 2
RTECS AY4342000
TSCA Yes
HS Code 29309090
ToxicityLD50 oral in rat: > 15gm/kg
MSDS Information
ProviderLanguage
3-Carboxymethylthio-L-alanine English
SigmaAldrich English
ACROS English
ALFA English
S-Carboxymethyl-L-Cysteine Usage And Synthesis
Chemical Propertieswhite to slightly off-white amorphous powder
OriginatorRhinathiol,Kramer,Switz.
Usescarbocysteine is an amino acid. It can be used to help control sebum production.
UsesCarbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).
UsesLabeled Carbocisteine, intended for use as an internal standard for the quantification of Carbocisteine by GC- or LC-mass spectrometry.
DefinitionChEBI: S-carboxymethyl-L-cysteine is an L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group. It has a role as a mucolytic. It is a L-cysteine thioether and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a S-carboxylatomethyl-L-cysteine(1-).
Manufacturing ProcessThere were placed 120g of L-cysteine (0.5 mol) in a 2 liter three-necked flask equipped with a stirrer thermometer and methanol/dry ice cooling and 1.5 liters of liquid ammonia were allowed to enter at -40°C. Then there were added under continuous cooling 50 g (2.17 mols) of sodium metal in portions of 1 to 2 g during the course of one hour. The end of the reaction was recognized by the continuation of the blue color. After the end of the reaction the excess sodium was destroyed by the addition of ammonium chloride and the ammonia vaporized at normal pressure. The residue was taken up in 500 ml of water and concentrated in a vacuum to 200 ml in order to remove residual ammonia, and again treated with 300 ml of water. The entire operations were carried out under a nitrogen atmosphere.
The aqueous solution of the disodium salt of L-cysteine obtained is then reacted at 20°C to 30°C under a nitrogen atmosphere in the course of 30 minutes with stirring with a solution of 104 g of chloroacetic acid (1.1 mols) and 4 g of sodium pyrosulfite in 200 ml of water. It is also allowed to post react for 15 minutes at 20°C, the solution clarified over activated carbon and the filtrate treated with 90 ml of concentrated hydrochloric acid to a pH of 2.5.
Thereby the S-carboxymethyl-L-cysteine precipitates out in crystalline form. The product is filtered off with suction, well stirred in 500 ml of water, again filtered with suction and dried in a vacuum at 70°C. The yield is 92% based on L-cysteine.

Brand nameLoviscol (Wyeth-Ayerst); Mucofan (Wyeth-Ayerst).
Therapeutic FunctionMucolytic, Expectorant, Nasal antiinfective
Biochem/physiol ActionsS-Carboxymethyl-L-cysteine is studied as a small molecule mucoactive drug in vivo. These studies include analyzing the oxidative metabolism of S-carboxymethyl-L-cysteine by enzymes such as phenylalanine monooxygenase(s).
Safety Profilecontact. A riot control agent. When heated
S-Carboxymethyl-L-Cysteine Preparation Products And Raw materials
Raw materialsChloroacetic acid-->Sodium metabisulfite-->L-Cysteine-->L-Cysteine monohydrochloride-->S-Carboxymethyl-L-cysteine-->Sodium
Preparation Productscarbocysteine sulfoxide-->N-acetyl-S-(2-carboxymethyl)cysteine
Carboxymethyl starch Sodium carboxyl methylstarch METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Carboxymethyl cellulose S-Carboxymethyl-L-cysteine SALCOMINE L-Alanine 2,4-PENTANEDIONE, SILVER DERIVATIVE Sodium carboxymethyl cellulose COBALT(II) ACETYLACETONATE L-Cysteine S-Carboxymethyl-L-Cysteine TERT-BUTYL ISOCYANIDE 3-(Methylseleno)-L-alanine COBALT ETHYLENE DIAMINE CHLORIDE Benzyl isocyanide Carboxymethyl chitosan

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