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| | Potassium borohydride Basic information |
| | Potassium borohydride Chemical Properties |
| Hazard Codes | F,T,C | | Risk Statements | 14/15-24/25-34-11 | | Safety Statements | 26-36/37/39-43-45-7/8-28A-16 | | RIDADR | UN 1870 4.3/PG 1 | | WGK Germany | - | | RTECS | TS7525000 | | F | 10 | | TSCA | Yes | | HS Code | 2850 00 20 | | HazardClass | 4.3 | | PackingGroup | I | | Toxicity | LD50 orally in Rabbit: 167 mg/kg LD50 dermal Rabbit 230 mg/kg |
| | Potassium borohydride Usage And Synthesis |
| Chemical Properties | White, crystalline powder. Stable
in moist and dry air, stable in vacuum to 500C,
decomposed by acids with evolution of hydrogen.
Partially soluble in water and ammonia; insoluble
in ethers and hydrocarbons.
| | Uses | Reducing agent; source of H-. | | Uses | Source of hydrogen, reducing agent for aldehydes, ketones, acid chlorides; foaming agent for plasticsPotassium borohydride is used as a selective reducing agent for ketones, aldehydes and acid chlorides. It is used as a precursor in the production of chloramphenicol, vitamin A, thiopenicol, atropine and scopolamine. It is used to prepare high dispersive copper nanoparticles by the chemical reduction method using potassium borohydride as a reducing agent. | | General Description | Potassium borohydride is a white crystalline or powdered solid. When exposed to water Potassium borohydride may react violently and start a fire. Potassium borohydride is toxic by ingestion. Potassium borohydride is used to make other chemicals. | | Air & Water Reactions | Highly flammable. When exposed to water Potassium borohydride may react violently and start a fire. Produce flammable gases on contact with water. May ignite on contact with water or moist air. | | Reactivity Profile | A reducing agent. Reacts rapidly and dangerously with oxygen and with other oxidizing agents, even weak ones. Thus, they are likely to ignite on contact with alcohols. Hydrides are incompatible with acids, alcohols, amines, and aldehydes. | | Hazard | Flammable, dangerous fire risk. Toxic by
ingestion.
| | Health Hazard | Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution. | | Fire Hazard | Produce flammable gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Runoff may create fire or explosion hazard. | | Safety Profile | Poison by ingestion.
Burns quietly in air. When heated to decomposition it emits toxic fumes of K2O.
See also BORON COMPOUNDS and
HYDRIDES. | | Purification Methods | Crystallise it from liquid ammonia. It is slowly hydrolysed by H2O. Its solubility at ~20o in H2O or liquid NH3 is 20%, in MeOH it is 0.7%, in Me2NCHO it is 15% and in MeOH/H2O (1:4) it is 13%. [Jons & Wallbridge Progr Inorg Chem 11 99-231 1970.] |
| | Potassium borohydride Preparation Products And Raw materials |
| Raw materials | Methanol-->Sodium borohydride-->Hydrogen-->Orthoboric acid-->Isoquinoline-1-carboxylic acid | | Preparation Products | Terfenadine-->Fluoxetine-->Paclobutrazol-->Bromadiolone-->Zopiclone-->Ticlopidine-->β-Estradiol-->FENFLURAMINE-->Lorcainide-->Diniconazole-->Diclobutrazol-->Diborane-->Brodifacoum-->3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene-->Paclobutrazol W.P.-->1,7-HEPTANEDIOL-->Deprodone propionate-->3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol-->Triadimenol-->Tropic acid-->Methoxydienone-->3-[1,1'-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthol-->3-(-Hydroxyphenethyl)-2-imino thiazolidine-->Bromhexine hydrochloride-->Gliclazide-->A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER-->21-Iodo-16-methylpregna-1,4,9(11)-trien-17-ol-3,20-dione-->N-(4-chlorophenyl)-1-isopropylpiperidin-4-amine-->Clorprenaline-->CLENBUTEROL-->Megestrol acetate-->2-AMINO-3,5-DIBROMOBENZYL ALCOHOL-->1-(2-CHLOROPHENYL)-2-BROMOETHANOL-->Trimebutine maleate-->1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide-->3-Nitrobenzyl alcohol-->13-ethyl-3-methoxygona-2,5(10)-dien-17beta-ol-->Labetalol-->3-Amino-3-azabicyclo[3.3.0]octane hydrochloride-->1-Phenyl-1-propanol |
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