ChemicalBook Product Catalog Pharmaceutical intermediates Bulk Drug Intermediates 5-Fluoroindole

5-Fluoroindole

5-Fluoroindole Basic information
Product Name:5-Fluoroindole
Synonyms:5-FLUORO-3-METHYLINDOLE;1H-Indole, 5-fluoro-;5-FLUOROINDOLE(5FI);5- Fluoroindole,5-Fluoro-1H-indole;5-Fluoroindole, 98% 1GR;NSC 88613;5-Fluoroindole 98%;Indole, 5-fluoro-
CAS:399-52-0
MF:C8H6FN
MW:135.14
EINECS:206-917-4
Product Categories:Indoles;Indole Series;Simple Indoles;Indole;Building Blocks;Heterocyclic Building Blocks;CHIRAL CHEMICALS;Fluorinated heterocyclic series;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Building Blocks;C7 to C9;Chemical Synthesis;Fluorinated Building Blocks;blocks;FluoroCompounds;IndolesOxindoles;Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives;Heterocyclic Building Blocks
Mol File:399-52-0.mol
5-Fluoroindole Structure
5-Fluoroindole Chemical Properties
Melting point 45-48 °C (lit.)
Boiling point 120 °C / 1mmHg
density 1.1203 (estimate)
Fp >230 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Crystalline Powder
pka16.16±0.30(Predicted)
color Off-white
BRN 112350
CAS DataBase Reference399-52-0(CAS DataBase Reference)
NIST Chemistry Reference1H-indole, 5-fluoro-(399-52-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
F 10
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
5-Fluoro-1H-indole English
ACROS English
SigmaAldrich English
ALFA English
5-Fluoroindole Usage And Synthesis
Chemical Propertiesoff-white crystalline powder
Uses• ;Reactant for preparation of 5-HT6 receptor ligands1• ;Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• ;Reactant for preparation of antitumor agents3• ;Reactant for preparation of antibacterial agents4• ;Reactant for preparation of immunosuppressive agents5• ;Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes6• ;Reactant for preparation of Myeloperoxidase Inhibitors7• ;Reactant fo
Uses5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.
Uses
  • Reactant for preparation of 5-HT6 receptor ligands
  • Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
  • Reactant for preparation of antitumor agents
  • Reactant for preparation of antibacterial agents
  • Reactant for preparation of immunosuppressive agents
  • Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes
  • Reactant for preparation of Myeloperoxidase Inhibitors
  • Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors
DefinitionChEBI: An organofluorine compound that is the 5-fluoro derivative of indole.
N,N-DIETHYL-4,5,6,7-TETRAFLUORO-3-INDOLEACETAMIDE 5-FLUORO-DL-TRYPTOPHAN Fluorine (S)-2-AMINO-3-(5-FLUORO-1H-INDOL-3-YL)-PROPIONIC ACID 5-FLUORO-ALPHA-METHYLTRYPTAMINE HYDROCHLORIDE Indometacin Indole-3-butyric acid 5-Fluoroindole-2-One 4'-FLUORO-4-(8-FLUORO-1,3,4,5-TETRAHYDRO-2H-PYRIDOó4,3-B]INDOL-2-YL)BUTYROPHENONEHCL,99% 2-ETHYLFORMATE-5-FLUOROINDOLE,ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE,Ethyl 5-fluoroindole Indoline 4,5,6,7-TETRAFLUORO-3-INDOLEACETONITRILE 6-Chloro-5-fluoroindole 5-Fluoroindole Indole Indole-3-acetic acid 5-FLUOROINDOLE-3-CARBOXALDEHYDE 5-FLUOROINDOLE-3-ACETIC ACID
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