| | 5-Methyl-2-hexanone Basic information |
| | 5-Methyl-2-hexanone Chemical Properties |
| Melting point | -74 °C | | Boiling point | 145 °C (lit.) | | density | 0.814 g/mL at 25 °C (lit.) | | vapor density | 3.94 (vs air) | | vapor pressure | 4.5 mm Hg ( 20 °C) | | refractive index | n20/D 1.406(lit.) | | Fp | 106 °F | | storage temp. | Store below +30°C. | | solubility | water: soluble5.4g/L at 25°C | | form | Liquid | | color | Clear colorless | | Odor | pleasant odor | | Odor Threshold | 0.0021ppm | | explosive limit | 1.35-8.2%, 93°F | | Water Solubility | 5.4 g/L (20 ºC) | | BRN | 506163 | | Exposure limits | TLV-TWA 240 mg/m3 (50 ppm) (ACGIH). | | LogP | 1.88 at 25℃ | | CAS DataBase Reference | 110-12-3(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Hexanone, 5-methyl-(110-12-3) | | EPA Substance Registry System | Methyl isoamyl ketone (110-12-3) |
| Hazard Codes | Xn | | Risk Statements | 10-20 | | Safety Statements | 23-24/25 | | RIDADR | UN 2302 3/PG 3 | | WGK Germany | 1 | | RTECS | MP3850000 | | Autoignition Temperature | 797 °F | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29141910 | | Hazardous Substances Data | 110-12-3(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: 3200 mg/kg LD50 dermal Rabbit 8100 mg/kg |
| | 5-Methyl-2-hexanone Usage And Synthesis |
| Chemical Properties | MIAK is a colorless liquid with a pleasant,
fruity odor. | | Application | Methyl isoamyl ketone (MIAK) is used asa solvent for polymers, cellulose esters, nitrocellulose, cellulose acetatebutyrate, andacrylics, and vinyl copolymers. | | Uses | 5-Methyl-2-hexanone may be used to synthesize N,N′-bis(1,4-dimethylpentyl)-p-phenylenediamine (BMPPD) via reductive alkylation of p-nitroaniline in the presence of copper-based catalysts. | | Definition | ChEBI: 5-methyl-2-hexanone is a ketone. | | Preparation | 5-Methyl-2-hexanone is produced by condensation of acetone with isobutyraldehyde. This reaction may be carried out in one or two steps, in the liquid or in the gas phase. | | General Description | 5-methylhexan-2-one appears as a colorless liquid with a pleasant fruity odor. Less dense than water. Vapors heavier than air. Used as a solvent and for making other chemicals. | | Air & Water Reactions | Flammable. Slightly soluble in water. | | Reactivity Profile | Ketones, such as 5-Methyl-2-hexanone, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. | | Hazard | Moderate fire risk. Central nervous systemimpairment and upper respiratory tract irritant. | | Health Hazard | Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. | | Health Hazard | Exposure to MIAK can produce a strongnarcotic effect and irritation of the eyes andrespiratory tract. The oral toxicity, however,was found to be low in rats: 1670 mg/kg. | | Fire Hazard | HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | | Safety Profile | Moderately toxic by
ingestion and intraperitoneal routes. Mildly
toxic by inhalation and skin contact. A
flammable liquid when exposed to heat,
flame, or oxidzers. To fight fire, use dry
chemical, CO2, foam, fog. When heated to
decomposition it emits acrid smoke and
irritating fumes. | | Potential Exposure | MIAK is used as a solvent for
cellulose esters, acrylics, and vinyl copolymers. | | Shipping | UN23025-Methylhexan-2-one, Hazard Class: 3;
Labels: 3-Flammable liquid. | | Incompatibilities | Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, nitrated amines, azo,
diazo, azido compounds, carbamates, organic cyanates.
Attacks some plastics and coatings | | Waste Disposal | Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All
federal, state, and local environmental regulations must be
observed.
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| | 5-Methyl-2-hexanone Preparation Products And Raw materials |
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