S-Ethyl trifluorothioacetate was used to selectively trifluoroacetylate amino groups in proteins.
Synthesis Reference(s)
Journal of the American Chemical Society, 74, p. 4005, 1952 DOI:10.1021/ja01136a010
Purification Methods
If IR is free of OH bands then fractionally distil it; otherwise dilute the thio-ester with dry Et2O, wash with 5% KOH and H2O, dry over MgSO4 and fractionate it through an efficient column [Hauptschein et al. J Am Chem Soc 74 4005 1952]. [Beilstein 2 IV 567.] Powerful obnoxious odour.
S-ETHYL TRIFLUOROTHIOACETATE Preparation Products And Raw materials
