ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives Carboxylic acid esters and derivatives Allyl chloroformate

Allyl chloroformate

Allyl chloroformate Basic information
Product Name:Allyl chloroformate
Synonyms:ALLYLCHLOROFORMATE(ACF);Prop-1-enylchlorocarbonate;(Allyloxycarbonyl) chloride;Chloridocarbonic acid allyl;Chloridocarbonic acid allyl ester;Allyl chloroformate,97%;Alloc-Clallyloxycarbonylchloride;Chlorine forMic acid allyl ester
CAS:2937-50-0
MF:C4H5ClO2
MW:120.53
EINECS:220-916-6
Product Categories:Amine ProtectionProtection and Derivatization;Others;Peptide Synthesis;Protecting and Derivatizing Reagents;Specialty Synthesis;Pharmaceutical Intermediates;CHLOROFORMATES
Mol File:2937-50-0.mol
Allyl chloroformate Structure
Allyl chloroformate Chemical Properties
Melting point 106℃
Boiling point 109 °C
density 1.134 g/mL at 20 °C(lit.)
vapor pressure 3.67 psi ( 20 °C)
refractive index n20/D 1.422(lit.)
Fp 88 °F
storage temp. 2-8°C
solubility Chloroform
form Liquid
color Clear slightly yellow to light orange to reddish brown
OdorExtremely irritating, causes tears; pungent.
BRN 773915
Stability:Moisture Sensitive
CAS DataBase Reference2937-50-0(CAS DataBase Reference)
NIST Chemistry ReferenceAllyl chloroformate(2937-50-0)
EPA Substance Registry SystemCarbonochloridic acid, 2-propen-1-yl ester (2937-50-0)
Safety Information
Hazard Codes T+
Risk Statements 10-22-26-34
Safety Statements 26-28-36/37/39-45
RIDADR UN 1722 6.1/PG 1
WGK Germany 3
RTECS LQ5775000
F 19
HazardClass 6.1(b)
PackingGroup I
HS Code 29159000
Hazardous Substances Data2937-50-0(Hazardous Substances Data)
Toxicitymouse,LC50,inhalation,23100ug/m3 (23.1mg/m3),LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(5), Pg. 51, 1984.
MSDS Information
ProviderLanguage
Allyl chloroformate English
SigmaAldrich English
ACROS English
ALFA English
Allyl chloroformate Usage And Synthesis
Chemical PropertiesColorless liquid
UsesAllyl Chloroformate is used in the synthesis of poly(ethylene oxide) hybrid systems for therapeutic applications and drug delivery. Also used in the synthesis of benzothiazole derivatives with potent anti-tumor properties.
General DescriptionA colorless liquid with a pungent odor. Flash point 88°F. Corrosive to metals and tissue. Very toxic by inhalation, ingestion and/or skin contact. Vapors are heavier than air.
Air & Water ReactionsHighly flammable. Water reaction produces heat and acidic HCl. In the presence of moist air, corrosive hydrogen chloride is produced.
Reactivity ProfileAcid halides, such as Allyl chloroformate, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardVapor irritates eyes and respiratory tract. Contact with liquid causes eye and skin irritation, and ingestion irritates mouth and stomach.
Chemical ReactivityReactivity with Water Reacts slowly generating hydrogen chloride; Reactivity with Common Materials: Corrosive metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety ProfilePoison by inhalation and ingestion. Corrosive. Dangerous when exposed to heat, open flame (or sparks), or powerful oxidizers. Can react with oxidizing materials. To fight fire, use alcohol foam, spray or mist, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also ALLYL COMPOUNDS and ESTERS.
Allyl chloroformate Preparation Products And Raw materials
Preparation ProductsH-LYS(ALLOC)-OH-->N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine-->ALLYL METHYL ETHER-->Allyl methyl carbonate-->(S)-4-[(Allyloxycarbonyl)amino]butanoic acid-->1-(ALLYLOXYCARBONYL-OXY)-1 H-BENZOTRIAZOLE-->(S)-2-(allyloxycarbonylaMino)-6-(tert-butoxycarbonylaMino)hexanoic acid-->Carbamic acid, N-[(1R)-2-hydroxy-1-methylethyl]-, 2-propen-1-yl ester
Dacthal Lurasidone hydrochloride Lauryl chloroformate Butyl 2-chloroacetate Trioctyl trimellitate Cetyl chloroformate Heptyl chloroformate Cyclopentyl chloroformate Pentyl chloroformate Cyclohexyl chloroformate Allyl phenoxyacetate 2'-Hydroxy-3-phenylpropiophenone Isopropylparaben ALLYL FORMATE Diisopropyl azodicarboxylate Allylbenzene Chloroformate Allyl hexanoate
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