ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN

ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Basic information
Product Name:ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN
Synonyms:ANTI-DREBRIN;ANTI-DREBRIN, HUMAN;ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN;Anti-Drebrin antibody produced in rabbit
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MW:0
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Mol File:Mol File
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Structure
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Chemical Properties
storage temp. -20°C
form buffered aqueous solution
Safety Information
Hazard Codes Xn
Risk Statements 21/22
Safety Statements 36/37
WGK Germany -
MSDS Information
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SigmaAldrich English
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Usage And Synthesis
General DescriptionDrebrin is a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. It is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Three isoforms, E1 and E2 (embryonic) and A (adult), have been identified in the brain. An additional truncated form of drebrin A, s-drebrin/A2, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
Biochem/physiol ActionsDrebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. It colocalizes with actin filaments and dendritic-like cell processes and may be involved in actin remodeling. It binds to and dissociates F-actin stabilizing proteins such as α-actinin, fascin, and tropomyosin from actin filaments. It plays an important role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain.
ANTI-DEVELOPMENTALLY-REGULATED BRAIN PROTEIN Preparation Products And Raw materials

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